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- W3140231775 abstract "AIM:To study the chemical constituents from Houttuynia cordata and to test their antiplatelet aggregation activities.METHODS:The chemical constituents were isolated and purified by silica gel column chromatography and their structures were elucidated on the basis of spectral analysis.The antiplatelet aggregation activities were evaluated by Born's method,using rat PRP induced by ADP and thrombin.RESULTS:Nine alkaloids were isolated and their structures were identified as norcepharadione B (1),4,5-dioxodehydroasimilobine (2),cepharadione B (3),aristololactam B Ⅱ (4),aristololactam A Ⅱ (5),sauristolactam (6),piperolactam A (7),splendidine (8),and aristololactam F Ⅱ (9).Antiplatelet aggregation test indicated significant inhibitory activities of compounds 1,2,4-7,9 induced by ADP and 1,2,4,7 induced by thrombin.CONCLUSION:Compounds 2,6,7,9 were isolated from the genus Houttuynia for the first time.Compounds 1,2,4,7 showed significant inhibitory effects on both ADP-induced and thrombin-induced platelet aggregation." @default.
- W3140231775 created "2021-04-13" @default.
- W3140231775 creator A5090690232 @default.
- W3140231775 date "2011-01-01" @default.
- W3140231775 modified "2023-09-23" @default.
- W3140231775 title "Alkaloids from Houttuynia cordata and Their Antiplatelet Aggregation Activities" @default.
- W3140231775 hasPublicationYear "2011" @default.
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