FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140263102> ?p ?o ?g. }

• W3140263102 abstract "Dental pulp stem cells (DPSCs) possess self- renewal capability, multi-lineage differentiation potential, and can generate a dentin-pulp-like tissue in vivo, which is promising for tooth regeneration. To enlarge the cells resource of DPSCs and explore the feasibility of DPSCs- mediated immune therapy, it is prerequisite to investigate the immunological properties of DPSCs and the underlying mechanisms. Human DPSCs and peripheral blood mono- nuclear cells were isolated and cultured. Then we used lymphocytes proliferation assays, cytokines detection, Transwell cultures, neutralization experiments, and flow cytometry to examine the in vitro immune characteristics of DPSCs. We found that DPSCs failed to stimulate allo- geneic T cells proliferation and suppressed T cells prolif- eration, B cells proliferation, and mixed lymphocyte reaction. In addition, DPSCs could up-regulate IL-10, down-regulate the production of IL-2, IL-17, and IFN-c, and did not affect the production of IL-6. Monoclonal antibody against transforming growth factor-b1 restored the T cells proliferation inhibited by DPSCs. Moreover, the population of regulatory T cells increased significantly and T-helper 17 cells decreased significantly in peripheral blood mononuclear cells co-cultured with DPSCs. These data confirmed that DPSCs are low immunogenic, could inhibit the proliferation of lymphocytes, regulate the pro- duction of cytokines in vitro, and the secretion of trans- forming growth factor-b1 may be involved in this event." @default.
• W3140263102 created "2021-04-13" @default.
• W3140263102 creator A5029502611 @default.
• W3140263102 creator A5065788314 @default.
• W3140263102 date "2015-01-01" @default.
• W3140263102 modified "2023-09-27" @default.
• W3140263102 title "Dental pulp stem cells suppress the proliferation of lymphocytes via transforming growth factor-b1" @default.
• W3140263102 cites W1497240165 @default.
• W3140263102 cites W1723320005 @default.
• W3140263102 cites W1969696192 @default.
• W3140263102 cites W1988477032 @default.
• W3140263102 cites W2007624518 @default.
• W3140263102 cites W2014646480 @default.
• W3140263102 cites W2019269134 @default.
• W3140263102 cites W2023750983 @default.
• W3140263102 cites W2028239901 @default.
• W3140263102 cites W2034010324 @default.
• W3140263102 cites W2037915841 @default.
• W3140263102 cites W2041308307 @default.
• W3140263102 cites W2044875340 @default.
• W3140263102 cites W2051297632 @default.
• W3140263102 cites W2054991182 @default.
• W3140263102 cites W2056725513 @default.
• W3140263102 cites W2057023851 @default.
• W3140263102 cites W2058839233 @default.
• W3140263102 cites W2068521142 @default.
• W3140263102 cites W2078633109 @default.
• W3140263102 cites W2095287464 @default.
• W3140263102 cites W2095666785 @default.
• W3140263102 cites W2099078833 @default.
• W3140263102 cites W2104911039 @default.
• W3140263102 cites W2113854724 @default.
• W3140263102 cites W2116316981 @default.
• W3140263102 cites W2117247924 @default.
• W3140263102 cites W2119314438 @default.
• W3140263102 cites W2120010406 @default.
• W3140263102 cites W2122659446 @default.
• W3140263102 cites W2126134953 @default.
• W3140263102 cites W2130516299 @default.
• W3140263102 cites W2130946236 @default.
• W3140263102 cites W2136767600 @default.
• W3140263102 cites W2138946470 @default.
• W3140263102 cites W2144224215 @default.
• W3140263102 cites W2148226248 @default.
• W3140263102 cites W2150977474 @default.
• W3140263102 cites W2159358845 @default.
• W3140263102 cites W2162453787 @default.
• W3140263102 cites W2162819001 @default.
• W3140263102 cites W2167992899 @default.
• W3140263102 cites W2599127931 @default.
• W3140263102 hasPublicationYear "2015" @default.
• W3140263102 type Work @default.
• W3140263102 sameAs 3140263102 @default.
• W3140263102 citedByCount "0" @default.
• W3140263102 crossrefType "journal-article" @default.
• W3140263102 hasAuthorship W3140263102A5029502611 @default.
• W3140263102 hasAuthorship W3140263102A5065788314 @default.
• W3140263102 hasConcept C203014093 @default.
• W3140263102 hasConcept C2777400515 @default.
• W3140263102 hasConcept C28328180 @default.
• W3140263102 hasConcept C2908647359 @default.
• W3140263102 hasConcept C553184892 @default.
• W3140263102 hasConcept C71924100 @default.
• W3140263102 hasConcept C86803240 @default.
• W3140263102 hasConcept C95444343 @default.
• W3140263102 hasConcept C99454951 @default.
• W3140263102 hasConceptScore W3140263102C203014093 @default.
• W3140263102 hasConceptScore W3140263102C2777400515 @default.
• W3140263102 hasConceptScore W3140263102C28328180 @default.
• W3140263102 hasConceptScore W3140263102C2908647359 @default.
• W3140263102 hasConceptScore W3140263102C553184892 @default.
• W3140263102 hasConceptScore W3140263102C71924100 @default.
• W3140263102 hasConceptScore W3140263102C86803240 @default.
• W3140263102 hasConceptScore W3140263102C95444343 @default.
• W3140263102 hasConceptScore W3140263102C99454951 @default.
• W3140263102 hasLocation W31402631021 @default.
• W3140263102 hasOpenAccess W3140263102 @default.
• W3140263102 hasPrimaryLocation W31402631021 @default.
• W3140263102 hasRelatedWork W1152907334 @default.
• W3140263102 hasRelatedWork W1977876646 @default.
• W3140263102 hasRelatedWork W2025050313 @default.
• W3140263102 hasRelatedWork W2059858822 @default.
• W3140263102 hasRelatedWork W2078633109 @default.
• W3140263102 hasRelatedWork W2081578778 @default.
• W3140263102 hasRelatedWork W2085832445 @default.
• W3140263102 hasRelatedWork W2092440335 @default.
• W3140263102 hasRelatedWork W2099052096 @default.
• W3140263102 hasRelatedWork W2168080793 @default.
• W3140263102 hasRelatedWork W2464260680 @default.
• W3140263102 hasRelatedWork W250647969 @default.
• W3140263102 hasRelatedWork W2582123114 @default.
• W3140263102 hasRelatedWork W2623516657 @default.
• W3140263102 hasRelatedWork W2742705730 @default.
• W3140263102 hasRelatedWork W2747321868 @default.
• W3140263102 hasRelatedWork W2935486854 @default.
• W3140263102 hasRelatedWork W3030307086 @default.
• W3140263102 hasRelatedWork W170850030 @default.
• W3140263102 hasRelatedWork W2828663722 @default.
• W3140263102 isParatext "false" @default.
• W3140263102 isRetracted "false" @default.

• next