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• W3140273286 abstract "Background: Immune Checkpoint Inhibitors (ICI) have become a care standard in advanced non-small cell lung cancer (aNSCLC). Myeloid-Derived Suppressor Cells (MDSC) are potent immunity suppressors and may represent both a potential prognostic and a predictive biomarker. Neutrophil-to-Lymphocyte Ratio (NLR) is an inflammatory biomarker with a prognostic role in NSCLC. We hypothesized that MDSC levels correlate with NLR and overall survival (OS) in aNSCLC. Methods: Pretreatment immunophenotyping of total MDSC (HLA-DR–/CD33+/CD11b+), early-MDSC (e-MDSC: CD14–/CD15–), monocytic-MDSC (M-MDSC: CD14+/CD15–) and polymorphonuclear-MDSC (PMN-MDSC: CD14–/CD15+) was performed by flow cytometry in fresh blood. Spearman's rank correlation, univariate and multivariate Cox proportional hazard models were used for data analysis (SPSS Statistics v20). Results: 100 patients treated with ICI who received at least one previous platinum-based combination chemotherapy for stage III—IV NSCLC and 14 healthy donors were prospectively included; 93% smokers, median age 63 years (range 38–80); 60% non-squamous and 50% PDL1 ≥1%. Median PFS (mPFS) and mOS was 2.98 m (95% CI, 0.92–4.85) and 11.83 m (95% CI, 9.46–13.85). Pretreatment high-NLR, dichotomized at a ROC curve analyses cutoff value ≥5.17, and high level of total MDSC, defined by the median value as a cut-off (≥6.3%), were correlated with poor PFS (NLR: p = 0.042 and MDSC: p = 0.038) and OS (NLR: p < 0.0001 and MDSC: p = 0.004). Pretreatment low e-MDSC (<21.1%), were also associated with poor PFS (p = 0.02) and OS (p = 0.03). Both total MDSC (Spearman's rho = 0,40; p < 0.0001) and PMN-MDSC (Spearman's rho = 0.29; p < 0.0001) were positively correlated with NLR. Multivariate analyses confirmed that higher NLR and higher total MDSC levels were independently associated with shorter OS (NLR HR 3.45; p = 0.005 and total MDSC HR 3.24; p = 0.021). Conclusions: Our study suggests that a baseline circulating MDSC correlate with NLR. Higher total MDSC levels and higher NLR were negative prognostic factors. The role of MDSC appears interesting as a potential predictive and prognostic biomarker in NSCLC patients treated with ICI. Legal entity responsible for the study: Instituto de Investigación Sanitaria - Fundacion para la Investigación del Hospital Universitario la Fe. Funding: Roche Farma, S.A. Disclosure: All authors have declared no conflicts of interest." @default.
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• W3140273286 date "2021-04-01" @default.
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• W3140273286 title "165P Baseline circulating myeloid-derived suppressor cells correlate with neutrophil-to-lymphocyte ratio and overall survival in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors" @default.
• W3140273286 doi "https://doi.org/10.1016/s1556-0864(21)02007-4" @default.
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