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- W3140303592 abstract "Objective To study the variation and clinical significance of serum levels of surfactant proteins A(SP-A) and D(SP-D) among children with different degrees of bronchiolitis. Methods Seventy children with bronchiolitis were divided into acute(n=42) and recovery phase groups(n=28). According to the severity of symptoms,the acute phase group was further divided into severe(n=12) and mild subgroups(n=30). Another 26 children who were hospitalized in the same period due to non-infectious diseases and had not undergone surgery were used as the control group. Competitive enzyme-linked immunosorbent assay was performed to measure serum levels of SP-A and SP-D in each group. Results The acute phase group had significantly higher serum levels of SP-A and SP-D compared with the recovery phase(P0.01) and control groups(P0.01). Compared with the control group, the recovery phase group had elevated levels of SP-A and SP-D(P0.01). Within the acute phase group, serum levels of SP-A and SP-D in the severe subgroup were significantly higher than in the mild subgroup(P0.01). Conclusions Serum levels of SP-A and SP-D are significantly elevated in children with acute bronchiolitis, and severe cases have higher serum levels of SP-A and SP-D than mild cases. Even after the relief of clinical symptoms, serum levels of SP-A and SP-D remain high.These findings suggest that serum levels of SP-A and SP-D might be useful biomarkers for evaluating the severity of bronchiolitis among children." @default.
- W3140303592 created "2021-04-13" @default.
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- W3140303592 date "2013-01-01" @default.
- W3140303592 modified "2023-09-23" @default.
- W3140303592 title "Determination and clinical significance of serum surfactant proteins A and D in children with bronchiolitis" @default.
- W3140303592 hasPublicationYear "2013" @default.
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