Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140310014> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W3140310014 endingPage "1189" @default.
- W3140310014 startingPage "1180" @default.
- W3140310014 abstract "Rho kinase inhibitor fasudil hydrochloride has been shown to reduce cerebral vasospasm, to inhibit inflammation and apoptosis and to promote the recovery of neurological function. However, the effect of fasudil hydrochloride on claudin-5 protein expression has not been reported after cerebral ischemia/reperfusion. Therefore, this study sought to explore the effects of fasudil hydrochloride on blood-brain barrier permeability, growth-associated protein-43 and claudin-5 protein expression, and to further understand the neuroprotective effect of fasudil hydrochloride. A focal cerebral ischemia/reperfusion model was established using the intraluminal suture technique. Fasudil hydrochloride (15 mg/kg) was intraperitoneally injected once a day. Neurological deficit was evaluated using Longa’s method. Changes in permeability of blood-brain barrier were measured using Evans blue. Changes in RhoA, growth-associated protein-43 and claudin-5 protein expression were detected using immunohistochemistry and western blotting. Results revealed that fasudil hydrochloride noticeably contributed to the recovery of neurological function, improved the function of blood-brain barrier, inhibited RhoA protein expression, and upregulated growth-associated protein-43 and claudin-5 protein expression following cerebral ischemia/reperfusion. Results indicated that Rho kinase exhibits a certain effect on neurovascular damage following cerebral ischemia/reperfusion. Intervention targeted Rho kinase might be a new therapeutic target in the treatment of cerebral ischemia/reperfusion." @default.
- W3140310014 created "2021-04-13" @default.
- W3140310014 creator A5001978013 @default.
- W3140310014 creator A5007034991 @default.
- W3140310014 creator A5036651646 @default.
- W3140310014 creator A5053780153 @default.
- W3140310014 creator A5057242521 @default.
- W3140310014 creator A5063911616 @default.
- W3140310014 creator A5067344935 @default.
- W3140310014 creator A5068607867 @default.
- W3140310014 date "2013-01-01" @default.
- W3140310014 modified "2023-09-29" @default.
- W3140310014 title "Rho kinase A new target for treatment of cerebral ischemia/reperfusion injury" @default.
- W3140310014 hasPublicationYear "2013" @default.
- W3140310014 type Work @default.
- W3140310014 sameAs 3140310014 @default.
- W3140310014 citedByCount "0" @default.
- W3140310014 crossrefType "journal-article" @default.
- W3140310014 hasAuthorship W3140310014A5001978013 @default.
- W3140310014 hasAuthorship W3140310014A5007034991 @default.
- W3140310014 hasAuthorship W3140310014A5036651646 @default.
- W3140310014 hasAuthorship W3140310014A5053780153 @default.
- W3140310014 hasAuthorship W3140310014A5057242521 @default.
- W3140310014 hasAuthorship W3140310014A5063911616 @default.
- W3140310014 hasAuthorship W3140310014A5067344935 @default.
- W3140310014 hasAuthorship W3140310014A5068607867 @default.
- W3140310014 hasConcept C126322002 @default.
- W3140310014 hasConcept C184235292 @default.
- W3140310014 hasConcept C185592680 @default.
- W3140310014 hasConcept C201800478 @default.
- W3140310014 hasConcept C25498285 @default.
- W3140310014 hasConcept C2776048814 @default.
- W3140310014 hasConcept C2777093181 @default.
- W3140310014 hasConcept C2778402981 @default.
- W3140310014 hasConcept C2778609687 @default.
- W3140310014 hasConcept C2780114680 @default.
- W3140310014 hasConcept C42219234 @default.
- W3140310014 hasConcept C529278444 @default.
- W3140310014 hasConcept C541997718 @default.
- W3140310014 hasConcept C55493867 @default.
- W3140310014 hasConcept C62478195 @default.
- W3140310014 hasConcept C71924100 @default.
- W3140310014 hasConcept C98274493 @default.
- W3140310014 hasConceptScore W3140310014C126322002 @default.
- W3140310014 hasConceptScore W3140310014C184235292 @default.
- W3140310014 hasConceptScore W3140310014C185592680 @default.
- W3140310014 hasConceptScore W3140310014C201800478 @default.
- W3140310014 hasConceptScore W3140310014C25498285 @default.
- W3140310014 hasConceptScore W3140310014C2776048814 @default.
- W3140310014 hasConceptScore W3140310014C2777093181 @default.
- W3140310014 hasConceptScore W3140310014C2778402981 @default.
- W3140310014 hasConceptScore W3140310014C2778609687 @default.
- W3140310014 hasConceptScore W3140310014C2780114680 @default.
- W3140310014 hasConceptScore W3140310014C42219234 @default.
- W3140310014 hasConceptScore W3140310014C529278444 @default.
- W3140310014 hasConceptScore W3140310014C541997718 @default.
- W3140310014 hasConceptScore W3140310014C55493867 @default.
- W3140310014 hasConceptScore W3140310014C62478195 @default.
- W3140310014 hasConceptScore W3140310014C71924100 @default.
- W3140310014 hasConceptScore W3140310014C98274493 @default.
- W3140310014 hasIssue "13" @default.
- W3140310014 hasLocation W31403100141 @default.
- W3140310014 hasOpenAccess W3140310014 @default.
- W3140310014 hasPrimaryLocation W31403100141 @default.
- W3140310014 hasRelatedWork W1736142830 @default.
- W3140310014 hasRelatedWork W2021109388 @default.
- W3140310014 hasRelatedWork W2092436449 @default.
- W3140310014 hasRelatedWork W2106497350 @default.
- W3140310014 hasRelatedWork W2111673480 @default.
- W3140310014 hasRelatedWork W2355718805 @default.
- W3140310014 hasRelatedWork W2357890712 @default.
- W3140310014 hasRelatedWork W2359392951 @default.
- W3140310014 hasRelatedWork W2364952032 @default.
- W3140310014 hasRelatedWork W2365428676 @default.
- W3140310014 hasRelatedWork W2373143363 @default.
- W3140310014 hasRelatedWork W2373721221 @default.
- W3140310014 hasRelatedWork W2375727268 @default.
- W3140310014 hasRelatedWork W2380641785 @default.
- W3140310014 hasRelatedWork W2388423817 @default.
- W3140310014 hasRelatedWork W2392748603 @default.
- W3140310014 hasRelatedWork W2395196657 @default.
- W3140310014 hasRelatedWork W3030582278 @default.
- W3140310014 hasRelatedWork W3032889238 @default.
- W3140310014 hasRelatedWork W3142628399 @default.
- W3140310014 hasVolume "8" @default.
- W3140310014 isParatext "false" @default.
- W3140310014 isRetracted "false" @default.
- W3140310014 magId "3140310014" @default.
- W3140310014 workType "article" @default.