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- W3140322525 abstract "Antisense oligonucleotides have been used for a variety of purposes in microRNA (miRNA) research including functional evaluation, target recognition, and gene studies. Although several 99m Tc-radiolabeled oligo- nucleotides have been reported in antisense imaging, none of those were related to miRNA tracing. Moreover, sepa- ration after labeling was always required to achieve acceptable radiochemical purity. In this study, we prepared a 99m Tc-radiolabeled oligonucleotide under optimized conditions for the purpose of tracing miRNA. A 22mer anti-miRNA oligonucleotide (AMO) was designed com- pletely complementary to the sequence of mature miR-21. AMO probe modified with 2 0 -O-Methyl and phosphoro-" @default.
- W3140322525 created "2021-04-13" @default.
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- W3140322525 date "2015-01-01" @default.
- W3140322525 modified "2023-09-24" @default.
- W3140322525 title "Optimized Preparation of a 99m Tc-Radiolabeled Probe for Tracing MicroRNA" @default.
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