Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140322575> ?p ?o ?g. }
- W3140322575 abstract "After leukemia, tumors of the brain and spine are the second most common form of cancer in children. Despite advances in treatment, brain tumors remain a leading cause of death in pediatric cancer patients and survivors often suffer from life-long consequences of side effects of therapy. The 5-year survival rates, however, vary widely by tumor type, ranging from over 90% in more benign tumors to as low as 20% in the most aggressive forms such as glioblastoma. Even within historically defined tumor types such as medulloblastoma, molecular analysis identified biologically heterogeneous subgroups each with different genetic alterations, age of onset and prognosis. Besides molecularly driven patient stratification to tailor disease risk to therapy intensity, such a diversity demonstrates the need for more precise and disease-relevant pediatric brain cancer models for research and drug development. Here we give an overview of currently available in vitro and in vivo pediatric brain tumor models and discuss the opportunities that new technologies such as 3D cultures and organoids that can bridge limitations posed by the simplicity of monolayer cultures and the complexity of in vivo models, bring to accommodate better precision in drug development for pediatric brain tumors." @default.
- W3140322575 created "2021-04-13" @default.
- W3140322575 creator A5016355152 @default.
- W3140322575 creator A5028313889 @default.
- W3140322575 date "2021-04-01" @default.
- W3140322575 modified "2023-09-25" @default.
- W3140322575 title "In Vivo and Ex Vivo Pediatric Brain Tumor Models: An Overview" @default.
- W3140322575 cites W1495551511 @default.
- W3140322575 cites W1523710401 @default.
- W3140322575 cites W1535135245 @default.
- W3140322575 cites W1853879803 @default.
- W3140322575 cites W1905767511 @default.
- W3140322575 cites W1920080947 @default.
- W3140322575 cites W1949037014 @default.
- W3140322575 cites W1967753699 @default.
- W3140322575 cites W1971163936 @default.
- W3140322575 cites W1971412744 @default.
- W3140322575 cites W1972825083 @default.
- W3140322575 cites W1978086970 @default.
- W3140322575 cites W1980324442 @default.
- W3140322575 cites W1980500001 @default.
- W3140322575 cites W1983341583 @default.
- W3140322575 cites W1984629114 @default.
- W3140322575 cites W1985156459 @default.
- W3140322575 cites W1985615173 @default.
- W3140322575 cites W1985958520 @default.
- W3140322575 cites W1988184011 @default.
- W3140322575 cites W1990918868 @default.
- W3140322575 cites W1992981977 @default.
- W3140322575 cites W1995130016 @default.
- W3140322575 cites W1996423090 @default.
- W3140322575 cites W1998771818 @default.
- W3140322575 cites W1999490364 @default.
- W3140322575 cites W2001244335 @default.
- W3140322575 cites W2001249814 @default.
- W3140322575 cites W2002754034 @default.
- W3140322575 cites W2003422441 @default.
- W3140322575 cites W2003645883 @default.
- W3140322575 cites W2007945973 @default.
- W3140322575 cites W2010677999 @default.
- W3140322575 cites W2011129052 @default.
- W3140322575 cites W2011334551 @default.
- W3140322575 cites W2014189883 @default.
- W3140322575 cites W2018671779 @default.
- W3140322575 cites W2023795605 @default.
- W3140322575 cites W2025182825 @default.
- W3140322575 cites W2027102742 @default.
- W3140322575 cites W2031700674 @default.
- W3140322575 cites W2031968704 @default.
- W3140322575 cites W2032043292 @default.
- W3140322575 cites W2037389769 @default.
- W3140322575 cites W2045188553 @default.
- W3140322575 cites W2045295282 @default.
- W3140322575 cites W2046285899 @default.
- W3140322575 cites W2048043668 @default.
- W3140322575 cites W2048546023 @default.
- W3140322575 cites W2050648201 @default.
- W3140322575 cites W2052588647 @default.
- W3140322575 cites W2053349906 @default.
- W3140322575 cites W2055027888 @default.
- W3140322575 cites W2056040684 @default.
- W3140322575 cites W2060075467 @default.
- W3140322575 cites W2071123870 @default.
- W3140322575 cites W2082080058 @default.
- W3140322575 cites W2084113170 @default.
- W3140322575 cites W2088422474 @default.
- W3140322575 cites W2092567064 @default.
- W3140322575 cites W2094252236 @default.
- W3140322575 cites W2097109659 @default.
- W3140322575 cites W2098776492 @default.
- W3140322575 cites W2099167893 @default.
- W3140322575 cites W2103694596 @default.
- W3140322575 cites W2104917184 @default.
- W3140322575 cites W2117559539 @default.
- W3140322575 cites W2123035617 @default.
- W3140322575 cites W2129730239 @default.
- W3140322575 cites W2130552536 @default.
- W3140322575 cites W2131799762 @default.
- W3140322575 cites W2132778252 @default.
- W3140322575 cites W2143530087 @default.
- W3140322575 cites W2147051337 @default.
- W3140322575 cites W2149657074 @default.
- W3140322575 cites W2150699398 @default.
- W3140322575 cites W2153016097 @default.
- W3140322575 cites W2157388625 @default.
- W3140322575 cites W2158988231 @default.
- W3140322575 cites W2161535481 @default.
- W3140322575 cites W2162755712 @default.
- W3140322575 cites W2164671967 @default.
- W3140322575 cites W2164789880 @default.
- W3140322575 cites W2167240068 @default.
- W3140322575 cites W2168631000 @default.
- W3140322575 cites W2176722357 @default.
- W3140322575 cites W2218878453 @default.
- W3140322575 cites W2269026928 @default.
- W3140322575 cites W2286284214 @default.
- W3140322575 cites W2296654540 @default.
- W3140322575 cites W2311629398 @default.
- W3140322575 cites W2345323998 @default.
- W3140322575 cites W2366536035 @default.