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- W3140333551 abstract "เบาหวานในผปวยธาลสซเมยรนแรงลขสทธ แสงลทอง พ.บ., สมชาย อนทรศรพงษ พ.บ., ธญญา เชฏฐากล พ.บ.กลมงานอายรกรรม โรงพยาบาลมหาราชนครราชสมา อำเภอเมอง จงหวดนครราชสมา 30000Abstract: Diabetes Mellitus in Severe Thalassemia PatientsSanglutong L, Insiripong S, Chetthakul TDepartment of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima 30000(E-mail: lickhasit1986@gmail.com) Introduction: Thalassemia is a genetic disease mainly characterized by microcytic anemia. In cases of severe thalassemia, the patients may be importantly complicated by the excess iron accumulation at the pancreas easily leading to the emergence of diabetes mellitus. The aim of this study was to describe the diabetes in cases with severe thalassemia. Methods: This retrospective study recruited the severe thalassemia patients who had diabetes if the fasting plasma glucose (FPG) > 126 mg% after fasting for 8 hours between 2012 and 2016. Thalassemia was diagnosed based on the hemoglobin electrophoresis using the high performance liquid chromatography, Bio-Rad®, and the patients needed regular blood transfusion. Results: There were seven diabetic patients, one male (14.3 %) and six females (85.7%), five with beta thalassemia / Hb E and two with Hb AEBart-Constant-Spring disease. Their age ranged from 34 to 51, mean 39.6 + 5.6 years. The blood tests showed: FPG 205-696, mean 472.6 + 150.0 mg%, HbA1c6.5-10.5%, mean 8.6 + 1.6 %, Hb concentration 5.5-8.3, mean 7.2 + 1.0 g%, ferritin 2,898-7,591, mean 5,533 + 1,889 ng/ml. Every patient was treated with insulin. Conclusion: Severe thalassemia that had diabetes mellitus was mostly beta thalassemia / Hb E disease. All patients had high FPG, but Hb A1c was only slightly increased, not proportional to FPG. So Hb A1c should not be used for diagnosing or monitoring diabetes in patients with severe thalassemia." @default.
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- W3140333551 date "2018-01-01" @default.
- W3140333551 modified "2023-09-23" @default.
- W3140333551 title "Diabetes Mellitus in Severe Thalassemia Patients" @default.
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