FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140333556> ?p ?o ?g. }

• W3140333556 abstract "NK2 homeobox 5 (Nkx2.5), a homeobox-containing transcription factor, is associated with a spectrum of congenital heart diseases. Recently, Nkx2.5 was also found to be differentially expressed in several kinds of tumors. In colorectal cancer (CRC) tissue and cells, hypermethylation of Nkx2.5 was observed. However, the roles of Nkx2.5 in CRC cells have not been fully elucidated. In the present study, we assessed the relationship between Nkx2.5 and CRC by analyzing the expression pattern of Nkx2.5 in CRC samples and the adjacent normal colonic mucosa (NCM) samples, as well as in CRC cell lines. We found higher expression of Nkx2.5 in CRC compared with NCM samples. CRC cell lines with poorer differentiation also had higher expression of Nkx2.5. Although this expression pattern makes Nkx2.5 seem like an oncogene, in vitro and in vivo tumor suppressive effects of Nkx2.5 were detected in HCT116 cells by establishing Nkx2.5-overexpressed CRC cells. However, Nkx2.5 overexpression was incapacitated in SW480 cells. To further assess the mechanism, different expression levels and mutational status of p53 were observed in HCT116 and SW480 cells. The expression of p21 WAF1/CIP1 , a downstream antitumor effector of p53, in CRC cells depends on both expression level and mutational status of p53. Overexpressed Nkx2.5 could elevate the expression of p21 WAF1/CIP1 only in CRC cells with wild-type p53 (HCT116), rather than in CRC cells with mutated p53 (SW480). Mechanistically, Nkx2.5 could interact with p53 and increase the transcription of p21 WAF1/CIP1 without affecting the expression of p53. In conclusion, our findings demonstrate that Nkx2.5 could act as a conditional tumor suppressor gene in CRC cells with respect to the mutational status of p53. The tumor suppressive effect of Nkx2.5 could be mediated by its role as a transcriptional coactivator in wild-type p53-mediated p21 WAF1/CIP1 expression." @default.
• W3140333556 created "2021-04-13" @default.
• W3140333556 creator A5000945121 @default.
• W3140333556 creator A5003891258 @default.
• W3140333556 creator A5007273737 @default.
• W3140333556 creator A5007278530 @default.
• W3140333556 creator A5035701638 @default.
• W3140333556 creator A5038454267 @default.
• W3140333556 creator A5043871243 @default.
• W3140333556 creator A5048125285 @default.
• W3140333556 creator A5052267876 @default.
• W3140333556 creator A5053275663 @default.
• W3140333556 creator A5067612393 @default.
• W3140333556 creator A5074028169 @default.
• W3140333556 creator A5079375938 @default.
• W3140333556 creator A5091599281 @default.
• W3140333556 date "2021-04-01" @default.
• W3140333556 modified "2023-10-17" @default.
• W3140333556 title "Nkx2.5 Functions as a Conditional Tumor Suppressor Gene in Colorectal Cancer Cells via Acting as a Transcriptional Coactivator in p53-Mediated p21 Expression" @default.
• W3140333556 cites W143445416 @default.
• W3140333556 cites W1640635403 @default.
• W3140333556 cites W1650797637 @default.
• W3140333556 cites W1835193415 @default.
• W3140333556 cites W1872124794 @default.
• W3140333556 cites W1890916383 @default.
• W3140333556 cites W1903324674 @default.
• W3140333556 cites W1964298852 @default.
• W3140333556 cites W1966163762 @default.
• W3140333556 cites W1966841369 @default.
• W3140333556 cites W1966971933 @default.
• W3140333556 cites W1971183940 @default.
• W3140333556 cites W1972798599 @default.
• W3140333556 cites W1974775172 @default.
• W3140333556 cites W1976969187 @default.
• W3140333556 cites W1979094848 @default.
• W3140333556 cites W1981786945 @default.
• W3140333556 cites W1986268367 @default.
• W3140333556 cites W1986900031 @default.
• W3140333556 cites W1988451304 @default.
• W3140333556 cites W1991148840 @default.
• W3140333556 cites W1991917274 @default.
• W3140333556 cites W1993841973 @default.
• W3140333556 cites W1995856480 @default.
• W3140333556 cites W1997191259 @default.
• W3140333556 cites W2003363961 @default.
• W3140333556 cites W2004537703 @default.
• W3140333556 cites W2011994306 @default.
• W3140333556 cites W2012293213 @default.
• W3140333556 cites W2015347860 @default.
• W3140333556 cites W2015519364 @default.
• W3140333556 cites W2023599593 @default.
• W3140333556 cites W2027406988 @default.
• W3140333556 cites W2039611809 @default.
• W3140333556 cites W2040686597 @default.
• W3140333556 cites W2040876807 @default.
• W3140333556 cites W2048482194 @default.
• W3140333556 cites W2049527615 @default.
• W3140333556 cites W2049541444 @default.
• W3140333556 cites W2058015620 @default.
• W3140333556 cites W2062745595 @default.
• W3140333556 cites W2063158632 @default.
• W3140333556 cites W2068234941 @default.
• W3140333556 cites W2069368388 @default.
• W3140333556 cites W2069452349 @default.
• W3140333556 cites W2074125063 @default.
• W3140333556 cites W2074222004 @default.
• W3140333556 cites W2075300416 @default.
• W3140333556 cites W2076600697 @default.
• W3140333556 cites W2077561395 @default.
• W3140333556 cites W2078963047 @default.
• W3140333556 cites W2080125477 @default.
• W3140333556 cites W2080646870 @default.
• W3140333556 cites W2081894694 @default.
• W3140333556 cites W2084147994 @default.
• W3140333556 cites W2085207827 @default.
• W3140333556 cites W2089218510 @default.
• W3140333556 cites W2093829713 @default.
• W3140333556 cites W2096751146 @default.
• W3140333556 cites W2097644950 @default.
• W3140333556 cites W2101015327 @default.
• W3140333556 cites W2103272211 @default.
• W3140333556 cites W2105973186 @default.
• W3140333556 cites W2111837850 @default.
• W3140333556 cites W2126679757 @default.
• W3140333556 cites W2127397312 @default.
• W3140333556 cites W2127937876 @default.
• W3140333556 cites W2136306650 @default.
• W3140333556 cites W2141285914 @default.
• W3140333556 cites W2142830238 @default.
• W3140333556 cites W2146040216 @default.
• W3140333556 cites W2146642286 @default.
• W3140333556 cites W2147242002 @default.
• W3140333556 cites W2147297736 @default.
• W3140333556 cites W2150525034 @default.
• W3140333556 cites W2152118923 @default.
• W3140333556 cites W2162262059 @default.
• W3140333556 cites W2163083846 @default.
• W3140333556 cites W2163565167 @default.
• W3140333556 cites W2165582255 @default.
• W3140333556 cites W2433637509 @default.

• next