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- W3140418904 abstract "Objective To observe the protein expression of growth associated protein-43(GAP-43) in midbrain ventral tegmental area in morphine withdrawal rats at different time, and to evaluate the effect of GAP-43 on morphine withdrawal memory. Methods Rat models of morphine dependent 1 week, 2 weeks and 4 weeks were established by morphine hydrochloride intraperitoneal injection with increasing doses to establish natural withdrawal. The protein expression of GAP-43 in midbrain ventral tegmental area was observed by immunohistochemical staining and the results were analyzed by Image-Pro Plus 5.1 image analysis system. Results With prolongation of dependent time, the expression of GAP-43 was decreased then increased in midbrain ventral tegmental area. Conclusion GAP-43 could play a role in morphine withdrawal memory in midbrain ventral tegmental area." @default.
- W3140418904 created "2021-04-13" @default.
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- W3140418904 date "2013-01-01" @default.
- W3140418904 modified "2023-09-26" @default.
- W3140418904 title "Expression of GAP-43 in Midbrain Ventral Tegmental Area of Morphine Withdrawal Rats" @default.
- W3140418904 hasPublicationYear "2013" @default.
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