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- W3140423786 abstract "cytokine p19 和 IL-12 的 p40 子单元填写了的 Interleukin (IL )-23, ，能从激活的 T 房间提高记忆 T 房间和 IFN- 的生产的增长。它能也在鼠科的模型导致 antitumor 效果。为了推进，在 vivo 评估 antitumor 活动和 IL-23 的有免疫力的改进，鼠科的结肠癌房间 retrovirally，有 mIL-23 基因的 transduced 皮下地被注射(s.c ) 进 BALB/c mice.Survival，时间和肿瘤体积被观察。LDH 版本试金，[3H ]-TdR 加入试金和 ELISA 被用来决定 CTL 活动， splenocytes 的增长和 cytokines 的水平分别地。树枝状的房间(DC ) 的数字被流动 cytometry (FCM ) 分析。Colon26/IL-23 房间分泌的 IL-23 压制了肿瘤的生长并且延长了老鼠， splenocytes 的提高的增长， CTL 活动，和 DC 的数字的幸存时间。IL-23 也支持了象 IFN- ， IL-12 和 TNF-o 那样的 Th1 cytokines 的生产。然而， IL-4 的水平没显著地被提高。这些数据建议肿瘤房间分泌的 IL-23 能由提高有免疫力的反应导致 antitumor 活动。" @default.
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- W3140423786 date "2006-01-01" @default.
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- W3140423786 title "Antitumor Activity and Immune Enhancement of Murine Interleukin-23 Expressed in Murine Colon Carcinoma Cells" @default.
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