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- W3140446246 abstract "背景 Atrial 纤维性颤动是有多因素的致病的普通心律不齐。最近，在在 KCNE4 基因的位置 1057 点的单个核苷酸多型性( G/T )，导致 glutamic 酸( Glu ， E ) /aspartic 酸(毒蛇， D )在位置 145 KCNE4 肽点的替换，在我们与自发的 atrial 纤维性颤动(与 KCNE4 145D 更经常的 atrial 纤维性颤动)要联系的实验室被发现。然而， KCNE4 145E/Dpolymorphism 的功能的效果仍然是我们构造了的 unknown.Methods KCNE4 (145E/D ) 表示 plasmids 并且短暂地 co-transfected 他们与进中国仓鼠 ovary-K1 房间并且识别单个核苷酸多型性的可能的功能的后果的执行整个房间的夹钳补丁的记录的 KCNQ1 基因。量的数据被学生的 t 测试分析。不到 0.05 被认为统计上重要的概率价值。结果 A 慢慢地激活的、非使 O 失去活性的电压依赖者电流((24.0 畯汢? 慨湲獥？" @default.
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- W3140446246 date "2007-01-01" @default.
- W3140446246 modified "2023-09-26" @default.
- W3140446246 title "Modulation of KCNQ1 current by atrial fibrillation-associated KCNE4 （145E/D） gene polymorphism" @default.
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