FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140562433> ?p ?o ?g. }

• W3140562433 abstract "Abstract Background Cystic echinococcosis (CE) affects predominantly young patients in highly endemic areas. Improved serological methods are needed for the follow-up of CE cases, especially given the high rates of post-surgical relapse that require detection as soon as possible. Methods We designed a study to investigate the value of antigenic proteins extracted from Echinococcus granulosus ( E. granulosus ) protoscoleces, and of recombinant B2t and 2B2t proteins, for assessing the efficacy of surgical treatment carried out on CE-affected children. This study was performed on 278 plasma samples collected from 59 Tunisian children surgically treated for CE and monitored for 3 years post-surgery. The patients were classified according to post-surgical outcomes into a “non-relapsed” (NRCE) and a “relapsed” (RCE) group. We performed in-house ELISAs to measure anti-B2t and anti-2B2t IgG and immunoblotting for the detection of IgG against SDS-PAGE-resolved E. granulosus protoscoleces-specific antigens. The Wilcoxon test was applied to assess anti-B2t and anti-2B2t IgG levels. We applied the Cochran Q test to compare the distribution of immunoblotting antigenic bands between 1-month and 1-year post-surgery. Results The probability of being “relapse-free” when a decrease in antibody titers occurred between 1 month and 1 year post-surgery was 81% and 75%, respectively, for anti-B2t and anti-2B2t IgG. We identified five protoscolex protein bands of 20, 26/27, 30, 40 and 46 kDa as highly immunoreactive by immunoblot for both RCE and NRCE patients at 1 month post-surgery, and significantly lower immunoreactivity after 1 year ( p < 10 –4 ) for NRCE compared to RCE patients. The proteins at 26/27 and 40 kDa displayed the best performance in predicting the outcome, with an 84% probability of being relapse-free when the reactivity against the 40 kDa antigen, the doublet at 26/27 kDa, or both was absent or disappeared between 1 month and 1 year post-surgery, and a 93% probability of being relapsed when both bands remained reactive or increased in intensity between the two time points. Conclusions The B2t protein could be useful for the prediction of CE early post-surgical outcomes. The proteins of E. granulosus protoscoleces, especially the doublet P26/27 and P40, could be promising predictive biomarkers for the post-surgical follow-up of CE cases as well. Graphical Abstract" @default.
• W3140562433 created "2021-04-13" @default.
• W3140562433 creator A5009904850 @default.
• W3140562433 creator A5021819902 @default.
• W3140562433 creator A5024486465 @default.
• W3140562433 creator A5044125006 @default.
• W3140562433 creator A5054794084 @default.
• W3140562433 creator A5059628540 @default.
• W3140562433 creator A5061003564 @default.
• W3140562433 creator A5062773179 @default.
• W3140562433 creator A5064096989 @default.
• W3140562433 creator A5068660747 @default.
• W3140562433 date "2021-03-30" @default.
• W3140562433 modified "2023-10-06" @default.
• W3140562433 title "Promising proteins detected by Western blot from Echinococcus granulosus protoscoleces for predicting early post-surgical outcomes in CE-affected Tunisian children" @default.
• W3140562433 cites W1823185412 @default.
• W3140562433 cites W1883543096 @default.
• W3140562433 cites W1965299712 @default.
• W3140562433 cites W1968925874 @default.
• W3140562433 cites W1983833075 @default.
• W3140562433 cites W1988860177 @default.
• W3140562433 cites W1996698242 @default.
• W3140562433 cites W2006747408 @default.
• W3140562433 cites W2010968994 @default.
• W3140562433 cites W2018645540 @default.
• W3140562433 cites W2035943513 @default.
• W3140562433 cites W2043173552 @default.
• W3140562433 cites W2058819379 @default.
• W3140562433 cites W2062146513 @default.
• W3140562433 cites W2063233634 @default.
• W3140562433 cites W2077957195 @default.
• W3140562433 cites W2080158224 @default.
• W3140562433 cites W2095497807 @default.
• W3140562433 cites W2105258332 @default.
• W3140562433 cites W2109367588 @default.
• W3140562433 cites W2110480356 @default.
• W3140562433 cites W2110867744 @default.
• W3140562433 cites W2124933130 @default.
• W3140562433 cites W2145257317 @default.
• W3140562433 cites W2151072964 @default.
• W3140562433 cites W2157412748 @default.
• W3140562433 cites W2198951039 @default.
• W3140562433 cites W2409326826 @default.
• W3140562433 cites W2571861007 @default.
• W3140562433 cites W2589303484 @default.
• W3140562433 cites W2589725155 @default.
• W3140562433 cites W2592279603 @default.
• W3140562433 cites W2891578205 @default.
• W3140562433 cites W2985731717 @default.
• W3140562433 cites W3153155441 @default.
• W3140562433 cites W4211043378 @default.
• W3140562433 cites W4233522674 @default.
• W3140562433 cites W4249650204 @default.
• W3140562433 cites W56269056 @default.
• W3140562433 doi "https://doi.org/10.1186/s13071-021-04679-5" @default.
• W3140562433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8008569" @default.
• W3140562433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33781311" @default.
• W3140562433 hasPublicationYear "2021" @default.
• W3140562433 type Work @default.
• W3140562433 sameAs 3140562433 @default.
• W3140562433 citedByCount "3" @default.
• W3140562433 countsByYear W31405624332022 @default.
• W3140562433 countsByYear W31405624332023 @default.
• W3140562433 crossrefType "journal-article" @default.
• W3140562433 hasAuthorship W3140562433A5009904850 @default.
• W3140562433 hasAuthorship W3140562433A5021819902 @default.
• W3140562433 hasAuthorship W3140562433A5024486465 @default.
• W3140562433 hasAuthorship W3140562433A5044125006 @default.
• W3140562433 hasAuthorship W3140562433A5054794084 @default.
• W3140562433 hasAuthorship W3140562433A5059628540 @default.
• W3140562433 hasAuthorship W3140562433A5061003564 @default.
• W3140562433 hasAuthorship W3140562433A5062773179 @default.
• W3140562433 hasAuthorship W3140562433A5064096989 @default.
• W3140562433 hasAuthorship W3140562433A5068660747 @default.
• W3140562433 hasBestOaLocation W31405624331 @default.
• W3140562433 hasConcept C104317684 @default.
• W3140562433 hasConcept C141071460 @default.
• W3140562433 hasConcept C142724271 @default.
• W3140562433 hasConcept C147483822 @default.
• W3140562433 hasConcept C159654299 @default.
• W3140562433 hasConcept C190612196 @default.
• W3140562433 hasConcept C203014093 @default.
• W3140562433 hasConcept C2776415932 @default.
• W3140562433 hasConcept C2777028278 @default.
• W3140562433 hasConcept C2779687537 @default.
• W3140562433 hasConcept C2780423258 @default.
• W3140562433 hasConcept C2909003041 @default.
• W3140562433 hasConcept C32611913 @default.
• W3140562433 hasConcept C42972112 @default.
• W3140562433 hasConcept C45189115 @default.
• W3140562433 hasConcept C55493867 @default.
• W3140562433 hasConcept C71924100 @default.
• W3140562433 hasConcept C86803240 @default.
• W3140562433 hasConcept C90856448 @default.
• W3140562433 hasConcept C90924648 @default.
• W3140562433 hasConceptScore W3140562433C104317684 @default.
• W3140562433 hasConceptScore W3140562433C141071460 @default.
• W3140562433 hasConceptScore W3140562433C142724271 @default.
• W3140562433 hasConceptScore W3140562433C147483822 @default.
• W3140562433 hasConceptScore W3140562433C159654299 @default.

• next