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- W3140617080 abstract "Objective: To investigate the transmembrane transport mechanism of tetrahydropalmatine(THP) in MDCK-MDR1 cell line.Methods: The bi-directional transport characteristics of THP with or without verapamil,which was a specific inhibitor of P-glycoprotein(P-gp),was observed in MDCK-MDR1 cell line.The effects of temperature and concentration of THP on the absorption of THP were also investigated.The concentration of THP was determined by HPLC method and the apparent permeability coefficient(Papp) of THP was calculated.Results: In the presence of 100 μg/ml verapamil,the Pappof THP from apices of cell monolayers(A) to bases of cell monolayers(B) was increased,while that from B to A was significantly reduced.In the absence of verapamil,the efflux rate value was 5.5,which was reduced to 3.9 in the presence of verapamil.Conclusion: The transport of THP in MDCK-MDR1 cell monolayers is effluxed by P-gp.THP may be a substrate of P-gp.The transmembrane transport of THP in MDCK-MDR1 cell monolayers is found to be temperature dependent and there is concentration saturation." @default.
- W3140617080 created "2021-04-13" @default.
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- W3140617080 date "2012-01-01" @default.
- W3140617080 modified "2023-09-25" @default.
- W3140617080 title "Transmembrane transport mechanism of tetrahydropalmatine in MDCK-MDR1 cell line" @default.
- W3140617080 hasPublicationYear "2012" @default.
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