FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140623213> ?p ?o ?g. }

• W3140623213 endingPage "411" @default.
• W3140623213 startingPage "405" @default.
• W3140623213 abstract "The purpose of this study is the development and validation of a novel and robust genotyping method for a new lysyl oxidase-like 1 (LOXL1) intronic polymorphism (rs11638944, C > G) and the investigation of its potential association with pseudoexfoliation syndrome (PXS) and pseudoexfoliation glaucoma (PXG) in a Greek population.242 DNA samples from 49 PXS, 64 PXG, 50 primary open-angle glaucoma (POAG) patients and 79 healthy age-matched controls were analyzed. Novel methodologies were developed and optimized, in order to genotype the intronic LOXL1 polymorphism: a) a real-time qPCR and melting curve analysis in the Light Cycler platform for rapid and cost-effective analysis and, b) a conventional PCR-RFLP method for analysis of a small number of samples. In selected samples, validity was checked with the reference DNA Sequencing method.The real-time qPCR methodology was reliable, demonstrating good efficiency, reproducibility, accuracy in genotyping (100% concordance with the PCR-RFLP method and DNA Sequencing), with good allele discrimination (Tm = 53.26°C for C allele, Tm = 61.83°C for G allele, ΔTm = 8.57°C). The results were characterized by Hardy-Weinberg equilibrium in all groups. An increase from 18% in healthy controls to 61% in PXS patients was detected for the G/G homozygote thus, the C allele is protective for PXS with OR = 0.22 (95%CI: 0.11-0.42, p < .0001). Moreover, an increase from 18% in healthy controls to 70% in PXG patients was detected for the G/G homozygote thus, the C allele is protective for PXG with OR = 0.13 (95%CI: 0.06-0.25, p < .0001).A statistically significant association was verified for the intronic LOXL1 polymorphism rs11638944 and PXS/PXG in a Greek population." @default.
• W3140623213 created "2021-04-13" @default.
• W3140623213 creator A5012819470 @default.
• W3140623213 creator A5020123731 @default.
• W3140623213 creator A5038851855 @default.
• W3140623213 creator A5088201067 @default.
• W3140623213 creator A5088778140 @default.
• W3140623213 creator A5089070652 @default.
• W3140623213 date "2021-04-01" @default.
• W3140623213 modified "2023-10-17" @default.
• W3140623213 title "Correlation of the intronic LOXL1 polymorphism rs11638944 with pseudoexfoliation syndrome and glaucoma in a Greek population" @default.
• W3140623213 cites W1914374322 @default.
• W3140623213 cites W1976421669 @default.
• W3140623213 cites W1985564676 @default.
• W3140623213 cites W1990378159 @default.
• W3140623213 cites W1996103258 @default.
• W3140623213 cites W2003838710 @default.
• W3140623213 cites W2019002861 @default.
• W3140623213 cites W2031288220 @default.
• W3140623213 cites W2034742711 @default.
• W3140623213 cites W2055170582 @default.
• W3140623213 cites W2081393706 @default.
• W3140623213 cites W2089792780 @default.
• W3140623213 cites W2090091671 @default.
• W3140623213 cites W2093030458 @default.
• W3140623213 cites W2115717891 @default.
• W3140623213 cites W2116379013 @default.
• W3140623213 cites W2118094114 @default.
• W3140623213 cites W2148977592 @default.
• W3140623213 cites W2161957190 @default.
• W3140623213 cites W2167653641 @default.
• W3140623213 cites W2326621723 @default.
• W3140623213 cites W2620042124 @default.
• W3140623213 cites W2777376269 @default.
• W3140623213 cites W2793592840 @default.
• W3140623213 cites W2811459875 @default.
• W3140623213 cites W2892360626 @default.
• W3140623213 cites W2899308387 @default.
• W3140623213 cites W3006630598 @default.
• W3140623213 cites W3008905349 @default.
• W3140623213 cites W3139602705 @default.
• W3140623213 cites W4211012086 @default.
• W3140623213 cites W1978372306 @default.
• W3140623213 cites W2018412721 @default.
• W3140623213 doi "https://doi.org/10.1080/13816810.2021.1904420" @default.
• W3140623213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33792495" @default.
• W3140623213 hasPublicationYear "2021" @default.
• W3140623213 type Work @default.
• W3140623213 sameAs 3140623213 @default.
• W3140623213 citedByCount "0" @default.
• W3140623213 crossrefType "journal-article" @default.
• W3140623213 hasAuthorship W3140623213A5012819470 @default.
• W3140623213 hasAuthorship W3140623213A5020123731 @default.
• W3140623213 hasAuthorship W3140623213A5038851855 @default.
• W3140623213 hasAuthorship W3140623213A5088201067 @default.
• W3140623213 hasAuthorship W3140623213A5088778140 @default.
• W3140623213 hasAuthorship W3140623213A5089070652 @default.
• W3140623213 hasConcept C104317684 @default.
• W3140623213 hasConcept C135763542 @default.
• W3140623213 hasConcept C153911025 @default.
• W3140623213 hasConcept C168007829 @default.
• W3140623213 hasConcept C169760540 @default.
• W3140623213 hasConcept C180754005 @default.
• W3140623213 hasConcept C2778527774 @default.
• W3140623213 hasConcept C2779541357 @default.
• W3140623213 hasConcept C2908647359 @default.
• W3140623213 hasConcept C31467283 @default.
• W3140623213 hasConcept C37463918 @default.
• W3140623213 hasConcept C49105822 @default.
• W3140623213 hasConcept C54355233 @default.
• W3140623213 hasConcept C71924100 @default.
• W3140623213 hasConcept C84133368 @default.
• W3140623213 hasConcept C86803240 @default.
• W3140623213 hasConcept C99454951 @default.
• W3140623213 hasConceptScore W3140623213C104317684 @default.
• W3140623213 hasConceptScore W3140623213C135763542 @default.
• W3140623213 hasConceptScore W3140623213C153911025 @default.
• W3140623213 hasConceptScore W3140623213C168007829 @default.
• W3140623213 hasConceptScore W3140623213C169760540 @default.
• W3140623213 hasConceptScore W3140623213C180754005 @default.
• W3140623213 hasConceptScore W3140623213C2778527774 @default.
• W3140623213 hasConceptScore W3140623213C2779541357 @default.
• W3140623213 hasConceptScore W3140623213C2908647359 @default.
• W3140623213 hasConceptScore W3140623213C31467283 @default.
• W3140623213 hasConceptScore W3140623213C37463918 @default.
• W3140623213 hasConceptScore W3140623213C49105822 @default.
• W3140623213 hasConceptScore W3140623213C54355233 @default.
• W3140623213 hasConceptScore W3140623213C71924100 @default.
• W3140623213 hasConceptScore W3140623213C84133368 @default.
• W3140623213 hasConceptScore W3140623213C86803240 @default.
• W3140623213 hasConceptScore W3140623213C99454951 @default.
• W3140623213 hasIssue "4" @default.
• W3140623213 hasLocation W31406232131 @default.
• W3140623213 hasLocation W31406232132 @default.
• W3140623213 hasOpenAccess W3140623213 @default.
• W3140623213 hasPrimaryLocation W31406232131 @default.
• W3140623213 hasRelatedWork W1663907732 @default.
• W3140623213 hasRelatedWork W1848053799 @default.

• next