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- W3140639847 abstract "Objective To investigate the effect of melatonin(MLT) on protein and mRNA expression of leptin(Lep) in subcutaneous fat tissue in insulin resistance(IR) rats.Methods Thirty seven Sprague-Dawley(SD) rats were randomly divided into model group(n=27) and control group(CN group,n=10).Rats in model group were fed with high glucose diet for 6 weeks.Twenty rats having developed IR in the model group were further randomly divided into two groups:IR group(n=10) and melatonin group(MLT group,n=10).Rats in CN group and MLT group were fed with 10mg/(kg.d) of standard chow or MLT,respectively,for 6 weeks from the beginning of the 7th week.At the end of the 12th week,the subcutaneous fat tissue was harvested from bilateral inguinal areas of the rats for the evaluation of the protein and mRNA expression of Lep by immunohistochemistry and RT-PCR.Results Systolic blood pressure(SBP),fasting serum leptin(Lep),triglycerides(TG),low density lipoprotein cholesterol(LDL-C),malondialdehyde(MDA) and homeostasis model assessment insulin resistance(HOMA-IR) were significantly lower(P0.01),while the serum superoxide dismutase(SOD) was significantly higher in MLT group compared with those in IR group(P0.01).The levels of fasting plasma glucose(FPG) and 2-hour postprandial plasma glucose(2hPPG) remained in normal range,and the body weight showed no significant difference among the three groups(P0.05).The protein and mRNA expressions of Lep in subcutaneous adipose tissue were significantly higher in IR group than in CN group(P0.01),while they were significantly lower in MLT group than in IR group(P0.01).Conclusion MLT may improve IR and the status of oxidation stress,and inhibit the over expression of Lep protein and mRNA in subcutaneous fat tissue in the high-glucose diet-induced IR rats." @default.
- W3140639847 created "2021-04-13" @default.
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- W3140639847 date "2014-01-01" @default.
- W3140639847 modified "2023-09-23" @default.
- W3140639847 title "Effect of melatonin on expression of leptin in subcutaneous fat tissue in insulin-resistant rats" @default.
- W3140639847 hasPublicationYear "2014" @default.
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