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- W3140651714 abstract "The aims of this study are to investigate the outcome and prognostic factors influencing long-term sur- vival on patients with acute promyelocytic leukemia (APL). A total of 340 APL patients admitted to the Department of Hematology from January 1988 to December 2009 were enrolled in this study. All patients received all-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO) with anthracy- cline-based induction therapy. After three courses of con- solidation chemotherapy, 279 patients received 2 years of maintenance therapy. Survival analyses were carried out using the Kaplan-Meier method and the Cox regression model. In total, 288 achieved CR with the CR rate of 84.7%, and 50 patients died during induction therapy. Univariate analysis identified the following three risk factors for hemor- rhagic mortality: fibrinogen level (1.0 g/l) (P = 0.0007), initial peripheral WBC count((4 9 10 9 /l) (P = 0.0001), as well as the presence of coagulopathy(P 0.0001). With a median follow-up of 49 (6-255) months, the estimated 5-year overall survival (OS) and relapse-free survival (RFS) were (89.0 ± 2.4)% and (83.7 ± 2.6)%, respectively. Cox regression analysis of the 290 patients showed initial WBC count, years of diagnosis, and the status of PML-RARa in remission seemed to be independent prognostic indicators for OS and RFS (P = 0.03, P 0.01 and P = 0.0001, respectively). Cytogenetics in addition to above three vari- ables remained significant for RFS (P = 0.01). Our retro- spective observations suggest that the combination of ATRA and/or ATO with anthracycline-based therapy may have useful implications in the perspective of long-term prognosis for adult APL." @default.
- W3140651714 created "2021-04-13" @default.
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- W3140651714 date "2011-01-01" @default.
- W3140651714 modified "2023-09-27" @default.
- W3140651714 title "Long-term survey of outcome in acute promyelocytic leukemia: a single center experience in 340 patients" @default.
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