Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140665762> ?p ?o ?g. }
- W3140665762 abstract "Transglutaminases (TGs) comprise a family of Ca 2? -dependent enzymes that catalyze protein cross-link- ing, which include nine family members in humans but only a single homolog in Drosophila with three conserved domains. Drosophila Tg plays important roles in cuticle morphogenesis, hemolymph clotting, and innate immunity. Mammalian tissue TG (TG2) is involved in polyglutamine diseases (polyQ diseases), and TG6 has been identified as a causative gene of a novel spinocerebellar ataxia, SCA35. Using a well-established SCA3 fly model, we found that RNA interference-mediated suppression of Tg aggravated polyQ-induced neurodegenerative phenotypes. The administration of cystamine, a known effective Tg inhibi- tor, enhanced ommatidial degeneration in SCA3 flies. We also demonstrated that the aggregates of pathogenic ataxin- 3 increased greatly, when the Tg activity was repressed. These findings indicate that Tg is crucial for polyQ- induced neurotoxicity because Tg ablation resulted in more severe neurodegeneration due to the elevated accumulation of insoluble ataxin-3 complexes in the SCA3 Drosophila model." @default.
- W3140665762 created "2021-04-13" @default.
- W3140665762 creator A5023145025 @default.
- W3140665762 creator A5025401935 @default.
- W3140665762 creator A5038053495 @default.
- W3140665762 date "2015-01-01" @default.
- W3140665762 modified "2023-09-24" @default.
- W3140665762 title "Inhibition of Transglutaminase Exacerbates Polyglutamine- Induced Neurotoxicity by Increasing the Aggregation of Mutant Ataxin-3 in an SCA3 Drosophila Model" @default.
- W3140665762 cites W147769263 @default.
- W3140665762 cites W1643390591 @default.
- W3140665762 cites W164897159 @default.
- W3140665762 cites W1892455234 @default.
- W3140665762 cites W1965896502 @default.
- W3140665762 cites W1969342645 @default.
- W3140665762 cites W1970608072 @default.
- W3140665762 cites W1971569225 @default.
- W3140665762 cites W1984332162 @default.
- W3140665762 cites W1986015652 @default.
- W3140665762 cites W1992341804 @default.
- W3140665762 cites W1993181722 @default.
- W3140665762 cites W1995354135 @default.
- W3140665762 cites W1996014020 @default.
- W3140665762 cites W2004916597 @default.
- W3140665762 cites W2005068210 @default.
- W3140665762 cites W2006808229 @default.
- W3140665762 cites W2007019333 @default.
- W3140665762 cites W2007552791 @default.
- W3140665762 cites W2010860980 @default.
- W3140665762 cites W2015211335 @default.
- W3140665762 cites W2021403237 @default.
- W3140665762 cites W2033179718 @default.
- W3140665762 cites W2036722948 @default.
- W3140665762 cites W2041904607 @default.
- W3140665762 cites W2053780437 @default.
- W3140665762 cites W2060750433 @default.
- W3140665762 cites W2062691596 @default.
- W3140665762 cites W2063731992 @default.
- W3140665762 cites W2064231174 @default.
- W3140665762 cites W2066863701 @default.
- W3140665762 cites W2077916002 @default.
- W3140665762 cites W2085673827 @default.
- W3140665762 cites W2100449612 @default.
- W3140665762 cites W2107046691 @default.
- W3140665762 cites W2111567059 @default.
- W3140665762 cites W2112476012 @default.
- W3140665762 cites W2127586082 @default.
- W3140665762 cites W2133092545 @default.
- W3140665762 cites W2135124405 @default.
- W3140665762 cites W2142716851 @default.
- W3140665762 cites W2143296539 @default.
- W3140665762 cites W2147766249 @default.
- W3140665762 cites W2168302341 @default.
- W3140665762 cites W2168434422 @default.
- W3140665762 cites W6590342 @default.
- W3140665762 cites W2065642138 @default.
- W3140665762 hasPublicationYear "2015" @default.
- W3140665762 type Work @default.
- W3140665762 sameAs 3140665762 @default.
- W3140665762 citedByCount "0" @default.
- W3140665762 crossrefType "journal-article" @default.
- W3140665762 hasAuthorship W3140665762A5023145025 @default.
- W3140665762 hasAuthorship W3140665762A5025401935 @default.
- W3140665762 hasAuthorship W3140665762A5038053495 @default.
- W3140665762 hasConcept C104317684 @default.
- W3140665762 hasConcept C142724271 @default.
- W3140665762 hasConcept C143065580 @default.
- W3140665762 hasConcept C166703698 @default.
- W3140665762 hasConcept C178498320 @default.
- W3140665762 hasConcept C181199279 @default.
- W3140665762 hasConcept C185592680 @default.
- W3140665762 hasConcept C2776041557 @default.
- W3140665762 hasConcept C2776925932 @default.
- W3140665762 hasConcept C2779134260 @default.
- W3140665762 hasConcept C2779500118 @default.
- W3140665762 hasConcept C55493867 @default.
- W3140665762 hasConcept C67705224 @default.
- W3140665762 hasConcept C71924100 @default.
- W3140665762 hasConcept C86803240 @default.
- W3140665762 hasConcept C95444343 @default.
- W3140665762 hasConceptScore W3140665762C104317684 @default.
- W3140665762 hasConceptScore W3140665762C142724271 @default.
- W3140665762 hasConceptScore W3140665762C143065580 @default.
- W3140665762 hasConceptScore W3140665762C166703698 @default.
- W3140665762 hasConceptScore W3140665762C178498320 @default.
- W3140665762 hasConceptScore W3140665762C181199279 @default.
- W3140665762 hasConceptScore W3140665762C185592680 @default.
- W3140665762 hasConceptScore W3140665762C2776041557 @default.
- W3140665762 hasConceptScore W3140665762C2776925932 @default.
- W3140665762 hasConceptScore W3140665762C2779134260 @default.
- W3140665762 hasConceptScore W3140665762C2779500118 @default.
- W3140665762 hasConceptScore W3140665762C55493867 @default.
- W3140665762 hasConceptScore W3140665762C67705224 @default.
- W3140665762 hasConceptScore W3140665762C71924100 @default.
- W3140665762 hasConceptScore W3140665762C86803240 @default.
- W3140665762 hasConceptScore W3140665762C95444343 @default.
- W3140665762 hasLocation W31406657621 @default.
- W3140665762 hasOpenAccess W3140665762 @default.
- W3140665762 hasPrimaryLocation W31406657621 @default.
- W3140665762 hasRelatedWork W1965825362 @default.
- W3140665762 hasRelatedWork W1972792035 @default.