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• W3140666822 abstract "Background: Sepsis is the commonest cause of neonatal mortality and is probably responsible for 30- 50% of the total neonatal deaths each year in developing countries. Diagnosis of neonatal sepsis remains a major challenge, as early signs of sepsis are often non-specific and the laboratory criteria are also not fully reliable. This leads to unnecessary exposure to antibiotics before the presence of sepsis has been proven with potentially poor outcomes. Several attempts have been made to use physiologic parameters, hematologic indices, and cytokine profiles, at the time of onset of the suspected sepsis episode to identify accurately neonates with sepsis. Elevated serum level of neopterin has been shown to be an early specific and sensitive marker responsible for activation of the cellular immune system and has also been proposed to aid in the diagnosis of bacterial infection. Objective: To evaluate the usefulness of serum neopterin level as an accurate diagnostic tool for neonatal sepsis and compare it with Rodwell's hematological sepsis score and C-reactive protein for predicting infection and outcome in neonates with sepsis. Methods: The study comprised 20 neonates with a clinical proven sepsis, 20 neonates with a clinical suspicion of sepsis and 20 healthy neonates of matched gestational age who were considered as the normal control group. All groups were subjected to full history taking and clinical examination. Laboratory investigations done were complete blood count, total and differential leucocytic count, blood culture, serum levels of CRP and neopterin. Results: Serum neopterin levels were significantly higher in the infected and suspected groups compared with the control group (p =0.0001) and correlated positively with both CRP levels (r=0.8, p =0.0001) and the Hematological Sepsis Score (r=0.5, p=0.04). Significant positive correlations were detected between serum neopterin level, maternal age (r=0.5, p=0.02), gravidity(r= 0.5, p = 0.01), respiratory distress (r= -0.5, p=0.03), and lethargy (r= 0.2, p=0.05) in septic neonates. Conclusion: Serum neopterin may be used as an early diagnostic tool with high sensitivity (78.09%), specificity (85%), positive predictive value (93.8%), negative predictive value (82.6%) in neonates with suspicion of sepsis especially when combined with routine hematological sepsis score and C-reactive protein." @default.
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• W3140666822 date "2011-01-01" @default.
• W3140666822 modified "2023-09-27" @default.
• W3140666822 title "Serum Neopterin Level in Early Onset Neonatal Sepsis" @default.
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