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• W3140670859 abstract "113-Plat Calmodulin Binding to a Novel Site in the AB Module of Kv7.2 Subunits Regulates Surface Expression Ganeko Bernardo-Seisdedos1, Juncal Fernandez-Orth1, Carolina Gomis-Perez1, Alessandro Alaimo1, Araitz Alberdi1, Covadonga Malo1, Pilar Areso2, Alvaro Villarroel1. CSIC, Leioa, Spain, UPV/EHU, Leioa, Spain. Calmodulin (CaM) binding to the ABmodule underliemultiplemechanisms governing the function of Kv7.2 subunits, which are the main component of the noninactivatingKþM-current, a key controller of neuronal excitability. Simultaneous binding to helix A and B is crucial for trafficking to the plasma membrane. We have identified a novel CaM-binding site located downstream of helix A, reminiscent of the TWmotif of CaM-gated SK2 Kþ channels, with W360 as pivotal for surface expression. In the context of the knownCaM-bindingmodes and previous studies, our data suggest a model for traffic control that involves alternative CaM docking to either helix B, the novel TW motif, or the IQ-site of helix A." @default.
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• W3140670859 date "2015-01-01" @default.
• W3140670859 modified "2023-10-07" @default.
• W3140670859 title "Alternative Splicing Modulates Kv Channel Clustering through a Molecular `Ball and Chain' Mechanism" @default.
• W3140670859 hasPublicationYear "2015" @default.
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