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• W3140687677 abstract "Upregulation of acetyl-CoA carboxylase (ACC), as a rate-limiting enzyme of fatty acid synthe- sis,has been recognized in multiple human cancers, impli- cating a critical role in cancer development and progression; yet, its role in gastric cancer still remains unclear. In the present study, we detected ACC and phos- phorylated form of ACC (pACC) expression in gastric cancers and explored its clinical significance. Tissue microarray blocks containing primary gastric cancer and adjacent normal mucosa specimens obtained from 1,072 Chinese patients were used for the detection of ACC and pACC expression by immunohistochemistry. Gastric can- cer cell lines were treated by metformin, and pACC was measured by Western blotting. ACC overexpression was observed in all the tumor specimens. High expression of pACC was found in 630 (58.8 %) of the 1,072 primary tumors and in 237 (66.6 %) of the 356 primary tumors without lymph node metastasis. Absent/low expression of pACC significantly correlated with advanced T stage (P 0.001), tumor size (P = 0.010), lymph node metas- tasis (P 0.001), advanced disease stage (P 0.001), and poor histological differentiation (P = 0.014) in 1,072 pri- mary tumors, and with advanced T stage (P = 0.015), tumor size (P = 0.017), and poor histological differentia- tion (P = 0.001) in 356 tumors without lymph node metastasis. Kaplan-Meier analysis showed that high expression of pACC is strongly related to better survival rates in all gastric cancer patients (P = 0.006). Cox regression analysis revealed that pACC is an independent prognostic factor only in patients without lymph node metastasis (P = 0.016). Metformin treatment leaded to increased expression of pACC, which, in turn, resulted in the reduction of cell proliferation and colony formation of gastric cancer cells (P 0.05). Increased activation of ACC is frequent in human gastric cancer, and downregu- lation of pACC is an important prognostic factor," @default.
• W3140687677 created "2021-04-13" @default.
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• W3140687677 date "2014-01-01" @default.
• W3140687677 modified "2023-09-24" @default.
• W3140687677 title "Increased expression of phospho-acetyl-CoA carboxylase protein is an independent prognostic factor for human gastric cancer without lymph node metastasis" @default.
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