SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140695134> ?p ?o ?g. }

Showing items 1 to 100 of ±114 with 100 items per page.

W3140695134 abstract "Summary The ERK5 MAP kinase signalling pathway drives transcription of naïve pluripotency genes in mouse Embryonic Stem Cells (mESCs). However, how ERK5 impacts on other aspects of mESC biology has not been investigated. Here, we employ quantitative proteomic profiling to identify proteins whose expression is regulated by the ERK5 pathway in mESCs. This reveals a function for ERK5 signalling in regulating dynamically expressed early embryonic 2-cell stage (2C) genes including the mESC rejuvenation factor ZSCAN4. ERK5-dependent ZSCAN4 induction in mESCs increases telomere length, a key rejuvenative process required for prolonged culture. Mechanistically, ERK5 promotes ZSCAN4 and 2C gene expression via transcription of the KLF2 pluripotency transcription factor. Surprisingly, ERK5 also directly phosphorylates KLF2 to drive ubiquitin-dependent degradation, encoding negative-feedback regulation of 2C gene expression. In summary, our data identify a regulatory module whereby ERK5 kinase and transcriptional activities bi-directionally control KLF2 levels to pattern dynamic 2C gene transcription and mESC rejuvenation." @default.
W3140695134 created "2021-04-13" @default.
W3140695134 creator A5000162520 @default.
W3140695134 creator A5009880855 @default.
W3140695134 creator A5018829184 @default.
W3140695134 creator A5022817590 @default.
W3140695134 creator A5037541385 @default.
W3140695134 creator A5038160617 @default.
W3140695134 creator A5056993485 @default.
W3140695134 creator A5065273868 @default.
W3140695134 creator A5065462299 @default.
W3140695134 creator A5066241536 @default.
W3140695134 creator A5067524265 @default.
W3140695134 creator A5075802762 @default.
W3140695134 creator A5078460066 @default.
W3140695134 creator A5080350638 @default.
W3140695134 creator A5082086405 @default.
W3140695134 date "2021-03-29" @default.
W3140695134 modified "2023-10-18" @default.
W3140695134 title "An ERK5-KLF2 signalling module regulates early embryonic gene expression dynamics and stem cell rejuvenation" @default.
W3140695134 cites W1966091621 @default.
W3140695134 cites W1969759973 @default.
W3140695134 cites W1975676532 @default.
W3140695134 cites W1984802615 @default.
W3140695134 cites W1989214935 @default.
W3140695134 cites W1991972495 @default.
W3140695134 cites W2005808461 @default.
W3140695134 cites W2013295681 @default.
W3140695134 cites W2029133125 @default.
W3140695134 cites W2034923684 @default.
W3140695134 cites W2035687698 @default.
W3140695134 cites W2058521801 @default.
W3140695134 cites W2061602742 @default.
W3140695134 cites W2088128367 @default.
W3140695134 cites W2109838780 @default.
W3140695134 cites W2126344344 @default.
W3140695134 cites W2134468110 @default.
W3140695134 cites W2136921951 @default.
W3140695134 cites W2146234609 @default.
W3140695134 cites W2154075930 @default.
W3140695134 cites W2236890339 @default.
W3140695134 cites W2503274052 @default.
W3140695134 cites W2524435562 @default.
W3140695134 cites W2526632574 @default.
W3140695134 cites W2565787913 @default.
W3140695134 cites W2609307548 @default.
W3140695134 cites W2612409496 @default.
W3140695134 cites W2747599497 @default.
W3140695134 cites W2809667147 @default.
W3140695134 cites W2810745552 @default.
W3140695134 cites W2938430282 @default.
W3140695134 doi "https://doi.org/10.1101/2021.03.29.435803" @default.
W3140695134 hasPublicationYear "2021" @default.
W3140695134 type Work @default.
W3140695134 sameAs 3140695134 @default.
W3140695134 citedByCount "0" @default.
W3140695134 crossrefType "posted-content" @default.
W3140695134 hasAuthorship W3140695134A5000162520 @default.
W3140695134 hasAuthorship W3140695134A5009880855 @default.
W3140695134 hasAuthorship W3140695134A5018829184 @default.
W3140695134 hasAuthorship W3140695134A5022817590 @default.
W3140695134 hasAuthorship W3140695134A5037541385 @default.
W3140695134 hasAuthorship W3140695134A5038160617 @default.
W3140695134 hasAuthorship W3140695134A5056993485 @default.
W3140695134 hasAuthorship W3140695134A5065273868 @default.
W3140695134 hasAuthorship W3140695134A5065462299 @default.
W3140695134 hasAuthorship W3140695134A5066241536 @default.
W3140695134 hasAuthorship W3140695134A5067524265 @default.
W3140695134 hasAuthorship W3140695134A5075802762 @default.
W3140695134 hasAuthorship W3140695134A5078460066 @default.
W3140695134 hasAuthorship W3140695134A5080350638 @default.
W3140695134 hasAuthorship W3140695134A5082086405 @default.
W3140695134 hasBestOaLocation W31406951341 @default.
W3140695134 hasConcept C104317684 @default.
W3140695134 hasConcept C138885662 @default.
W3140695134 hasConcept C145103041 @default.
W3140695134 hasConcept C150194340 @default.
W3140695134 hasConcept C165864922 @default.
W3140695134 hasConcept C179926584 @default.
W3140695134 hasConcept C2777350992 @default.
W3140695134 hasConcept C41895202 @default.
W3140695134 hasConcept C54355233 @default.
W3140695134 hasConcept C86339819 @default.
W3140695134 hasConcept C86803240 @default.
W3140695134 hasConcept C95444343 @default.
W3140695134 hasConceptScore W3140695134C104317684 @default.
W3140695134 hasConceptScore W3140695134C138885662 @default.
W3140695134 hasConceptScore W3140695134C145103041 @default.
W3140695134 hasConceptScore W3140695134C150194340 @default.
W3140695134 hasConceptScore W3140695134C165864922 @default.
W3140695134 hasConceptScore W3140695134C179926584 @default.
W3140695134 hasConceptScore W3140695134C2777350992 @default.
W3140695134 hasConceptScore W3140695134C41895202 @default.
W3140695134 hasConceptScore W3140695134C54355233 @default.
W3140695134 hasConceptScore W3140695134C86339819 @default.
W3140695134 hasConceptScore W3140695134C86803240 @default.
W3140695134 hasConceptScore W3140695134C95444343 @default.
W3140695134 hasLocation W31406951341 @default.
W3140695134 hasOpenAccess W3140695134 @default.
W3140695134 hasPrimaryLocation W31406951341 @default.