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- W3140736196 abstract "The liposome of small unilamellar vesicles (SUV) made from phosphatidylcholine-cholesterol mixtures was used as a simple model for biomimetic membranes. The studies on the interaction between the liposome and realgar nanoparticles (NPs) demonstrate that the phospholipid is one of the key targeted molecules of realgar NPs, used by surface plasmon resonance (SPR) technology, fluorescence polarization, Raman spectroscopy, nuclear magnetic resonance (NMR) and atom force microscope (AFM). It was observed that the relative viscosity (ηr) of the membrane increased and the membrane fluidity decreased as realgar NPs bound to SUV. Calculations of Raman intensity ratios detected the increase of longitudinal order parameters (Strans) and lateral order parameters (Slat) of the lipid bilayer, indicating a rise in the proportion of trans conformations of alkyl chains, and the decrease of membrane’s fluidity attributed to the interaction of realgar NPs. Results of Raman spectra and 31P NMR suggest that the polar headgroup of phospholipid is the interacted target site of realgar NPs. Moreover, time-lapse AFM images show that realgar NPs compromise the phospholipid membrane integrity to result in the formation of pore or hole." @default.
- W3140736196 created "2021-04-13" @default.
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- W3140736196 date "2009-01-01" @default.
- W3140736196 modified "2023-09-24" @default.
- W3140736196 title "Studies on the biomimetic membrane interaction between liposome and realgar nanoparticles" @default.
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