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- W3140741707 abstract "The microenvironment of an early-stage tumor, in which a small number of cancer cells is surrounded by a normal counterpart milieu, plays a crucial role in determining the fate of initiated cells. Here, we examined cell competition between anaplastic thyroid cancer cells and normal thyroid follicular cells using co-culture method. Cancer cells were grown until they formed small clusters, to which normal cells were added to create high-density co-culture condition. We found that co-culture with normal cells significantly suppressed the growth of cancer cell clusters through the activation of Akt-Skp2 pathway. In turn, cancer cells triggered apoptosis in the neighboring normal cells through local activation of ERK1/2. A bi-directional cell competition provides a suppressive mechanism of anaplastic thyroid cancer progression. Since the competitive effect was negated by terminal growth arrest caused by radiation exposure to normal cells, modulation of reciprocal stress response in vivo could be an intrinsic mechanism associated with tumor initiation, propagation, and metastasis." @default.
- W3140741707 created "2021-04-13" @default.
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- W3140741707 creator A5061184430 @default.
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- W3140741707 creator A5088043523 @default.
- W3140741707 date "2021-04-01" @default.
- W3140741707 modified "2023-09-26" @default.
- W3140741707 title "Cell competition between anaplastic thyroid cancer and normal thyroid follicular cells exerts reciprocal stress response defining tumor suppressive effects of normal epithelial tissue" @default.
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- W3140741707 doi "https://doi.org/10.1371/journal.pone.0249059" @default.
- W3140741707 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8016217" @default.
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- W3140741707 hasPublicationYear "2021" @default.
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