FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140839923> ?p ?o ?g. }

• W3140839923 endingPage "311" @default.
• W3140839923 startingPage "311" @default.
• W3140839923 abstract "For several decades, self-expanding metal stents (SEMSs) have shown significant clinical success in the palliation of obstructive metastatic oesophageal cancer. However, these conventional oesophageal stents can suffer from stent blockage caused by malignant tumour cell growth. To overcome this challenge, there is growing interest in drug-releasing stents that, in addition to palliation, provide a sustained and localized release of anticancer drugs to minimise tumour growth. Therefore, in this study we prepared and evaluated an oesophageal stent-based drug delivery platform to provide the sustained release of docetaxel (DTX) for the treatment of oesophageal cancer-related obstructions. The DTX-loaded oesophageal stents were fabricated via dip-coating of bare nitinol stents with DTX-polyurethane (PU) solutions to provide PU coated stents with DTX loadings of 1.92 and 2.79% w/w. Mechanical testing of the DTX-PU coated stents revealed that an increase in the drug loading resulted in a reduction in the ultimate tensile strength, toughness and Young’s modulus. In vitro release studies showed a sustained release of DTX, with ~80–90% released over a period of 33 days. While the DTX-loaded stents exhibited good stability to gamma radiation sterilisation, UV sterilisation or accelerated storage at elevated temperatures (40 °C) resulted in significant DTX degradation. Cell proliferation, apoptosis and Western blotting assays revealed that the DTX released from the stents had comparable anticancer activity to pure DTX against oesophageal cancer cells (KYSE-30). This research demonstrates that the dip-coating technique can be considered as a promising approach for the fabrication of drug-eluting stents (DESs) for oesophageal cancer treatment." @default.
• W3140839923 created "2021-04-13" @default.
• W3140839923 creator A5005301342 @default.
• W3140839923 creator A5011999968 @default.
• W3140839923 creator A5017636767 @default.
• W3140839923 creator A5026486245 @default.
• W3140839923 creator A5040796317 @default.
• W3140839923 creator A5052196710 @default.
• W3140839923 creator A5089852629 @default.
• W3140839923 date "2021-04-01" @default.
• W3140839923 modified "2023-10-16" @default.
• W3140839923 title "Drug-Loaded, Polyurethane Coated Nitinol Stents for the Controlled Release of Docetaxel for the Treatment of Oesophageal Cancer" @default.
• W3140839923 cites W118497669 @default.
• W3140839923 cites W1968037773 @default.
• W3140839923 cites W1970873407 @default.
• W3140839923 cites W1994907928 @default.
• W3140839923 cites W1995855968 @default.
• W3140839923 cites W1996739625 @default.
• W3140839923 cites W1999142756 @default.
• W3140839923 cites W2004758739 @default.
• W3140839923 cites W2007389503 @default.
• W3140839923 cites W2011484106 @default.
• W3140839923 cites W2012417871 @default.
• W3140839923 cites W2026334592 @default.
• W3140839923 cites W2036282614 @default.
• W3140839923 cites W2045874203 @default.
• W3140839923 cites W2053049013 @default.
• W3140839923 cites W2060417186 @default.
• W3140839923 cites W2070897741 @default.
• W3140839923 cites W2076022232 @default.
• W3140839923 cites W2089049259 @default.
• W3140839923 cites W2092655157 @default.
• W3140839923 cites W2100498588 @default.
• W3140839923 cites W2106917466 @default.
• W3140839923 cites W2151671742 @default.
• W3140839923 cites W2153417837 @default.
• W3140839923 cites W2164986334 @default.
• W3140839923 cites W2284051211 @default.
• W3140839923 cites W2329948173 @default.
• W3140839923 cites W2560322684 @default.
• W3140839923 cites W2565402466 @default.
• W3140839923 cites W2590790325 @default.
• W3140839923 cites W2594860653 @default.
• W3140839923 cites W2768237071 @default.
• W3140839923 cites W2937346106 @default.
• W3140839923 cites W2955346545 @default.
• W3140839923 cites W3023728168 @default.
• W3140839923 cites W3042431119 @default.
• W3140839923 cites W3046947391 @default.
• W3140839923 cites W3092148974 @default.
• W3140839923 cites W3093863708 @default.
• W3140839923 cites W3094796183 @default.
• W3140839923 cites W3117726923 @default.
• W3140839923 doi "https://doi.org/10.3390/ph14040311" @default.
• W3140839923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8067330" @default.
• W3140839923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33915787" @default.
• W3140839923 hasPublicationYear "2021" @default.
• W3140839923 type Work @default.
• W3140839923 sameAs 3140839923 @default.
• W3140839923 citedByCount "5" @default.
• W3140839923 countsByYear W31408399232021 @default.
• W3140839923 countsByYear W31408399232022 @default.
• W3140839923 countsByYear W31408399232023 @default.
• W3140839923 crossrefType "journal-article" @default.
• W3140839923 hasAuthorship W3140839923A5005301342 @default.
• W3140839923 hasAuthorship W3140839923A5011999968 @default.
• W3140839923 hasAuthorship W3140839923A5017636767 @default.
• W3140839923 hasAuthorship W3140839923A5026486245 @default.
• W3140839923 hasAuthorship W3140839923A5040796317 @default.
• W3140839923 hasAuthorship W3140839923A5052196710 @default.
• W3140839923 hasAuthorship W3140839923A5089852629 @default.
• W3140839923 hasBestOaLocation W31408399231 @default.
• W3140839923 hasConcept C121608353 @default.
• W3140839923 hasConcept C126322002 @default.
• W3140839923 hasConcept C136229726 @default.
• W3140839923 hasConcept C141071460 @default.
• W3140839923 hasConcept C159985019 @default.
• W3140839923 hasConcept C171250308 @default.
• W3140839923 hasConcept C192562407 @default.
• W3140839923 hasConcept C2778583881 @default.
• W3140839923 hasConcept C2779578285 @default.
• W3140839923 hasConcept C2779820397 @default.
• W3140839923 hasConcept C2781190966 @default.
• W3140839923 hasConcept C2781448156 @default.
• W3140839923 hasConcept C502942594 @default.
• W3140839923 hasConcept C71924100 @default.
• W3140839923 hasConceptScore W3140839923C121608353 @default.
• W3140839923 hasConceptScore W3140839923C126322002 @default.
• W3140839923 hasConceptScore W3140839923C136229726 @default.
• W3140839923 hasConceptScore W3140839923C141071460 @default.
• W3140839923 hasConceptScore W3140839923C159985019 @default.
• W3140839923 hasConceptScore W3140839923C171250308 @default.
• W3140839923 hasConceptScore W3140839923C192562407 @default.
• W3140839923 hasConceptScore W3140839923C2778583881 @default.
• W3140839923 hasConceptScore W3140839923C2779578285 @default.
• W3140839923 hasConceptScore W3140839923C2779820397 @default.
• W3140839923 hasConceptScore W3140839923C2781190966 @default.
• W3140839923 hasConceptScore W3140839923C2781448156 @default.

• next