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- W3140897922 abstract "Objective To investigate the polymorphisms of TAP2 gene in Chinese patients with HBV infection, chronic hepatitis B, hepatocirrhosis and individuals recovered from HBV infection. Methods The investigation covers 101 chronic hepatitis B patients and 21 subjects recovered from HBV infection. A healthy control panel of 113 subjects was collected from Shanghai Blood Center. All of the specimens subjected to the definition of the Blue Print of Prevention and Cure of Virosis Hepatitis-2000. TAP2 gene genotypes were determined by means of PCR-RFLP and ARMS-PCR, and their frequencies were compared. Results Frequency of TAP2*0201 in chronic hepatitis B was significantly lower than that in the recovered (χ2=4.95, P0.03). Frequency of TAP2*0101 in hepatocirrhosis was significantly higher than that in healthy control(χ2=5.72, P0.02); The TAP2*0101 allele was a strong linkage disequilibrium with HLA-DR4 in hepatocirrhosis in this study (△=0.026, P0.05). Conclusion These results suggested that TAP2*0101 allele might be associated with susceptibility of chronic hepatitis B and hepatocirrhosis in Shanghai patients, however TAP2*0201 revealed to be resistant to chronic hepatitis B. Both of the two alleles were closely associated with the prognosis of HBV infection." @default.
- W3140897922 created "2021-04-13" @default.
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- W3140897922 date "2005-01-01" @default.
- W3140897922 modified "2023-09-24" @default.
- W3140897922 title "Genetic polymorphisms of TAP2 in patients with hepatitis B virus infection" @default.
- W3140897922 hasPublicationYear "2005" @default.
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