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- W3140902221 abstract "Vulval extramammary Paget's disease (EMPD) can be classified based on the origin of the neoplastic Paget's cells as either primary or secondary. Primary EMPD can be further subdivided into a primary, intraepithelial cutaneous form with and without invasion or an intraepithelial cutaneous Paget's disease as a manifestation of underlying skin appendage adenocarcinoma. Secondary EMPD has an anorectal, urothelial or other origin. These subtypes can present similarly on the skin and may appear similar on routine hematoxylin and eosin-stained slides. Radiation therapy in selected cases may be feasible and may give good local control. This might be an alternative, particularly in medically inoperable patients. Targeted therapy with trastuzumab may be considered as a possible new therapeutic strategy in selected cases of vulval EMPD showing overexpression of HER-2/neu. Treatment can result in a significant regression of disease and resolution of symptoms." @default.
- W3140902221 created "2021-04-13" @default.
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- W3140902221 date "2017-01-14" @default.
- W3140902221 modified "2023-10-18" @default.
- W3140902221 title "Extramammary Paget's Disease" @default.
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- W3140902221 doi "https://doi.org/10.1002/9781119146087.ch20" @default.
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