FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140903131> ?p ?o ?g. }

• W3140903131 endingPage "28" @default.
• W3140903131 startingPage "16" @default.
• W3140903131 abstract "Threshold serum 25-hydroxyvitamin D [25(OH)D] concentrations for extraskeletal outcomes are uncertain and could differ from recommendations (20–30 ng/mL) for skeletal health. We aimed to identify and validate sex-specific threshold 25(OH)D concentrations for older adults’ physical function. Using 5 large prospective, population-based studies—Age, Gene/Environment Susceptibility-Reykjavik (n = 4858, Iceland); Health, Aging, and Body Composition (n = 2494, United States); Invecchiare in Chianti (n = 873, Italy); Osteoporotic Fractures in Men (n = 2301, United States); and Study of Osteoporotic Fractures (n = 5862, United States)—we assessed 16,388 community-dwelling adults (10,376 women, 6012 men) aged ≥65 y. We analyzed 25(OH)D concentrations with the primary outcome (incident slow gait: women <0.8 m/s; men <0.825 m/s) and secondary outcomes (gait speed, incident self-reported mobility, and stair climb impairment) at median 3.0-y follow-up. We identified sex-specific 25(OH)D thresholds that best discriminated incident slow gait using machine learning in training data (2/3 cohort-stratified random sample) and validated using the remaining (validation) data and secondary outcomes. Mean age in the cohorts ranged from 74.4 to 76.5 y in women and from 73.3 to 76.6 y in men. Overall, 1112/6123 women (18.2%) and 494/3937 men (12.5%) experienced incident slow gait, 1098/7011 women (15.7%) and 474/3962 men (12.0%) experienced incident mobility impairment, and 1044/6941 women (15.0%) and 432/3993 men (10.8%) experienced incident stair climb impairment. Slow gait was best discriminated by 25(OH)D <24.0 ng/mL compared with 25(OH)D ≥24.0 ng/mL in women (RR: 1.29; 95% CI: 1.10, 1.50) and 25(OH)D <21.0 ng/mL compared with 25(OH)D ≥21.0 ng/mL in men (RR: 1.43; 95% CI: 1.01, 2.02). Most associations between 25(OH)D and secondary outcomes were modest; estimates were similar between validation and training datasets. Empirically identified and validated sex-specific threshold 25(OH)D concentrations for physical function for older adults, 24.0 ng/mL for women and 21.0 ng/mL for men, may inform candidate reference concentrations or the design of vitamin D intervention trials." @default.
• W3140903131 created "2021-04-13" @default.
• W3140903131 creator A5000325789 @default.
• W3140903131 creator A5009080265 @default.
• W3140903131 creator A5012619895 @default.
• W3140903131 creator A5018378907 @default.
• W3140903131 creator A5021497564 @default.
• W3140903131 creator A5029506023 @default.
• W3140903131 creator A5034005943 @default.
• W3140903131 creator A5041374470 @default.
• W3140903131 creator A5048196698 @default.
• W3140903131 creator A5048605983 @default.
• W3140903131 creator A5056927598 @default.
• W3140903131 creator A5057919043 @default.
• W3140903131 creator A5059711314 @default.
• W3140903131 creator A5089876350 @default.
• W3140903131 creator A5090671996 @default.
• W3140903131 creator A5091334656 @default.
• W3140903131 date "2021-07-01" @default.
• W3140903131 modified "2023-10-16" @default.
• W3140903131 title "Sex-specific 25-hydroxyvitamin D threshold concentrations for functional outcomes in older adults: PRoject on Optimal VItamin D in Older adults (PROVIDO)" @default.
• W3140903131 cites W1501283868 @default.
• W3140903131 cites W1531695673 @default.
• W3140903131 cites W1976472175 @default.
• W3140903131 cites W1991254279 @default.
• W3140903131 cites W2000468033 @default.
• W3140903131 cites W2009187570 @default.
• W3140903131 cites W2034630727 @default.
• W3140903131 cites W2045257928 @default.
• W3140903131 cites W2064512935 @default.
• W3140903131 cites W2099665543 @default.
• W3140903131 cites W2100644604 @default.
• W3140903131 cites W2101419933 @default.
• W3140903131 cites W2103777411 @default.
• W3140903131 cites W2104750100 @default.
• W3140903131 cites W2110201971 @default.
• W3140903131 cites W2122291797 @default.
• W3140903131 cites W2122593814 @default.
• W3140903131 cites W2128659393 @default.
• W3140903131 cites W2139168999 @default.
• W3140903131 cites W2142702103 @default.
• W3140903131 cites W2142971300 @default.
• W3140903131 cites W2153059487 @default.
• W3140903131 cites W2153287976 @default.
• W3140903131 cites W2159147640 @default.
• W3140903131 cites W2159296038 @default.
• W3140903131 cites W2160121593 @default.
• W3140903131 cites W2167764115 @default.
• W3140903131 cites W2168801650 @default.
• W3140903131 cites W2314971059 @default.
• W3140903131 cites W2415412721 @default.
• W3140903131 cites W2489417614 @default.
• W3140903131 cites W2511955685 @default.
• W3140903131 cites W2570555403 @default.
• W3140903131 cites W2743297807 @default.
• W3140903131 cites W2765383321 @default.
• W3140903131 cites W2778170101 @default.
• W3140903131 cites W2799981123 @default.
• W3140903131 cites W2800235147 @default.
• W3140903131 cites W2802654868 @default.
• W3140903131 cites W2899572198 @default.
• W3140903131 cites W2944533085 @default.
• W3140903131 cites W2948994757 @default.
• W3140903131 cites W3099091911 @default.
• W3140903131 cites W3112762342 @default.
• W3140903131 cites W4248757416 @default.
• W3140903131 doi "https://doi.org/10.1093/ajcn/nqab025" @default.
• W3140903131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8246604" @default.
• W3140903131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33826696" @default.
• W3140903131 hasPublicationYear "2021" @default.
• W3140903131 type Work @default.
• W3140903131 sameAs 3140903131 @default.
• W3140903131 citedByCount "6" @default.
• W3140903131 countsByYear W31409031312022 @default.
• W3140903131 countsByYear W31409031312023 @default.
• W3140903131 crossrefType "journal-article" @default.
• W3140903131 hasAuthorship W3140903131A5000325789 @default.
• W3140903131 hasAuthorship W3140903131A5009080265 @default.
• W3140903131 hasAuthorship W3140903131A5012619895 @default.
• W3140903131 hasAuthorship W3140903131A5018378907 @default.
• W3140903131 hasAuthorship W3140903131A5021497564 @default.
• W3140903131 hasAuthorship W3140903131A5029506023 @default.
• W3140903131 hasAuthorship W3140903131A5034005943 @default.
• W3140903131 hasAuthorship W3140903131A5041374470 @default.
• W3140903131 hasAuthorship W3140903131A5048196698 @default.
• W3140903131 hasAuthorship W3140903131A5048605983 @default.
• W3140903131 hasAuthorship W3140903131A5056927598 @default.
• W3140903131 hasAuthorship W3140903131A5057919043 @default.
• W3140903131 hasAuthorship W3140903131A5059711314 @default.
• W3140903131 hasAuthorship W3140903131A5089876350 @default.
• W3140903131 hasAuthorship W3140903131A5090671996 @default.
• W3140903131 hasAuthorship W3140903131A5091334656 @default.
• W3140903131 hasBestOaLocation W31409031311 @default.
• W3140903131 hasConcept C124490489 @default.
• W3140903131 hasConcept C126322002 @default.
• W3140903131 hasConcept C144024400 @default.
• W3140903131 hasConcept C149923435 @default.
• W3140903131 hasConcept C1862650 @default.

• next