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• W3140930145 endingPage "135852" @default.
• W3140930145 startingPage "135852" @default.
• W3140930145 abstract "Testosterone (T) exerts anxiolytic effects through functional androgen receptors (ARs) in rodents. T treatment of castrated mice reduces anxiety-like behavior in wild-type (WT) males, but not males with a spontaneous mutation that renders AR dysfunctional (testicular feminization mutation, Tfm). Using Cre-LoxP technology we created males carrying induced dysfunctional AR allele (induced TFM; iTfm) to determine the brain regions responsible for T-induced anxiolysis. Adult WT and iTfm mice were castrated and T treated. Castrated WTs given a blank capsule (WT + B) served as additional controls. Mice were later exposed to the anxiogenic light/dark box, sacrificed and their brains processed for immediate early gene cFos immunoreactivity. Analyses revealed that T treatment increased cFos-expressing neurons in the basolateral amygdala (blAMY) of WT males, but not in iTfm males, which did not differ from WT + B mice. In contrast, WT + T males displayed fewer cFos + cells than iTfm + T or WT + B groups in the suprachiasmatic nucleus of the hypothalamus (SCN). No effects of genotype or hormone were seen in cFos expression in the hippocampus, medial prefrontal cortex, paraventricular nucleus of the hypothalamus, oval and anterodorsal bed nucleus of the stria terminalis, or dorsal periaqueductal grey. AR immunohistochemistry indicated that ∼65 % of cells in the blAMY and SCN were AR + in WT males, so AR could act directly within neurons in these regions to modulate the animals’ response to anxiogenic stimuli. Because absence of a functional AR did not affect cFos response to mild stress in the other brain regions, they are unlikely to mediate androgen’s anxiolytic effects." @default.
• W3140930145 created "2021-04-13" @default.
• W3140930145 creator A5011976319 @default.
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• W3140930145 date "2021-05-01" @default.
• W3140930145 modified "2023-10-02" @default.
• W3140930145 title "Testosterone works through androgen receptors to modulate neuronal response to anxiogenic stimuli" @default.
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• W3140930145 doi "https://doi.org/10.1016/j.neulet.2021.135852" @default.
• W3140930145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33785380" @default.
• W3140930145 hasPublicationYear "2021" @default.
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