FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W31409413> ?p ?o ?g. }

• W31409413 endingPage "205" @default.
• W31409413 startingPage "205" @default.
• W31409413 abstract "Fistulae represent an important complication in patient suffering from Crohn's disease (CD). Cumulative incidence of fistula formation in CD patients is 17%-50% and about one third of patients suffer from recurring fistulae formation. Medical treatment options often fail and also surgery frequently is not successful. Available data indicate that CD-associated fistulae originate from an epithelial defect that may be caused by ongoing inflammation. Having undergone epithelial to mesenchymal transition (EMT), intestinal epithelial cells (IEC) penetrate into deeper layers of the mucosa and the gut wall causing localized tissue damage formation of a tube like structure and finally a connection to other organs or the body surface. EMT of IEC may be initially aimed to improve wound repair mechanisms since conventional wound healing mechanisms, such as migration of fibroblasts, are impaired in CD patients. EMT also enhances activation of matrix remodelling enzymes such as matrix metalloproteinase (MMP)-3 and MMP-9 causing further tissue damage and inflammation. Finally, soluble mediators like TNF and interleukin-13 further induce their own expression in an autocrine manner and enhance expression of molecules associated with cell invasiveness aggravating the process. Additionally, pathogen-associated molecular patterns also seem to play a role for induction of EMT and fistula development. Though current knowledge suggests a number of therapeutic options, new and more effective therapeutic approaches are urgently needed for patients suffering from CD-associated fistulae. A better understanding of the pathophysiology of fistula formation, however, is a prerequisite for the development of more efficacious medical anti-fistula treatments." @default.
• W31409413 created "2016-06-24" @default.
• W31409413 creator A5058012401 @default.
• W31409413 creator A5058227847 @default.
• W31409413 date "2014-01-01" @default.
• W31409413 modified "2023-09-30" @default.
• W31409413 title "Pathophysiology of fistula formation in Crohn's disease" @default.
• W31409413 cites W1489553970 @default.
• W31409413 cites W1530146677 @default.
• W31409413 cites W1660096373 @default.
• W31409413 cites W1867633291 @default.
• W31409413 cites W1886431664 @default.
• W31409413 cites W1921554018 @default.
• W31409413 cites W1951491012 @default.
• W31409413 cites W1967073403 @default.
• W31409413 cites W1969204556 @default.
• W31409413 cites W1973073024 @default.
• W31409413 cites W1975021657 @default.
• W31409413 cites W1984438195 @default.
• W31409413 cites W1991158789 @default.
• W31409413 cites W1992623236 @default.
• W31409413 cites W1997452920 @default.
• W31409413 cites W1998975199 @default.
• W31409413 cites W2000512425 @default.
• W31409413 cites W2001535574 @default.
• W31409413 cites W2014280822 @default.
• W31409413 cites W2018299366 @default.
• W31409413 cites W2018620192 @default.
• W31409413 cites W2021033985 @default.
• W31409413 cites W2024701119 @default.
• W31409413 cites W2025771896 @default.
• W31409413 cites W2025839140 @default.
• W31409413 cites W2027628523 @default.
• W31409413 cites W2030585086 @default.
• W31409413 cites W2032533938 @default.
• W31409413 cites W2032942532 @default.
• W31409413 cites W2044570850 @default.
• W31409413 cites W2046371371 @default.
• W31409413 cites W2047289384 @default.
• W31409413 cites W2047992261 @default.
• W31409413 cites W2048550241 @default.
• W31409413 cites W2050431295 @default.
• W31409413 cites W2056766888 @default.
• W31409413 cites W2060763719 @default.
• W31409413 cites W2062268212 @default.
• W31409413 cites W2063134159 @default.
• W31409413 cites W2066188919 @default.
• W31409413 cites W2071214728 @default.
• W31409413 cites W2076045446 @default.
• W31409413 cites W2077462602 @default.
• W31409413 cites W2077627376 @default.
• W31409413 cites W2078009042 @default.
• W31409413 cites W2078621117 @default.
• W31409413 cites W2092804562 @default.
• W31409413 cites W2109681202 @default.
• W31409413 cites W2111727755 @default.
• W31409413 cites W2111861855 @default.
• W31409413 cites W2114769013 @default.
• W31409413 cites W2116644027 @default.
• W31409413 cites W2122738080 @default.
• W31409413 cites W2123937928 @default.
• W31409413 cites W2136976917 @default.
• W31409413 cites W2137401341 @default.
• W31409413 cites W2147240986 @default.
• W31409413 cites W2153284298 @default.
• W31409413 cites W2168938667 @default.
• W31409413 doi "https://doi.org/10.4291/wjgp.v5.i3.205" @default.
• W31409413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4133520" @default.
• W31409413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25133023" @default.
• W31409413 hasPublicationYear "2014" @default.
• W31409413 type Work @default.
• W31409413 sameAs 31409413 @default.
• W31409413 citedByCount "83" @default.
• W31409413 countsByYear W314094132015 @default.
• W31409413 countsByYear W314094132016 @default.
• W31409413 countsByYear W314094132017 @default.
• W31409413 countsByYear W314094132018 @default.
• W31409413 countsByYear W314094132019 @default.
• W31409413 countsByYear W314094132020 @default.
• W31409413 countsByYear W314094132021 @default.
• W31409413 countsByYear W314094132022 @default.
• W31409413 countsByYear W314094132023 @default.
• W31409413 crossrefType "journal-article" @default.
• W31409413 hasAuthorship W31409413A5058012401 @default.
• W31409413 hasAuthorship W31409413A5058227847 @default.
• W31409413 hasBestOaLocation W314094131 @default.
• W31409413 hasConcept C10162356 @default.
• W31409413 hasConcept C109523444 @default.
• W31409413 hasConcept C121608353 @default.
• W31409413 hasConcept C126322002 @default.
• W31409413 hasConcept C128240485 @default.
• W31409413 hasConcept C141071460 @default.
• W31409413 hasConcept C142724271 @default.
• W31409413 hasConcept C170493617 @default.
• W31409413 hasConcept C203014093 @default.
• W31409413 hasConcept C2776341189 @default.
• W31409413 hasConcept C2776914184 @default.
• W31409413 hasConcept C2779013556 @default.

• next