FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140954637> ?p ?o ?g. }

• W3140954637 endingPage "109038" @default.
• W3140954637 startingPage "109038" @default.
• W3140954637 abstract "Harmine is a beta-carboline and harmala alkaloid with extensive bioactivities. However, its toxicity, especially in neural system, is not systematically assessed and the toxic mechanism is not yet clear. Using Caenorhabditis elegans (C. elegans) as a model system, we found that harmine exhibited dosage dependent (0, 5, 10, 20, 40, 80, 160, and 320 μmol/L) toxic effect, such as growth inhibition, egg laying defects, shortened life span and increased mortality. Although harmine did not result in obvious structural alterations in neurite or death of neurons, it did show direct acetylcholinesterase inhibition activity. Further, we found that harmine treatment decreased worm pharyngeal pump rate and lowered the content of nitric oxide (NO) in worm body, implying foraging disorders, which is an indicator of acetylcholinergic neuron activity inhibition. Besides, network pharmacology and molecular docking reveals that acetylcholinesterase is one of the major neural toxicity targets as well. Above all, harmine can directly inhibit the activity of acetylcholinesterase, leading to excessive accumulation of acetylcholine, which may be one of the harmine neurotoxicity mechanisms." @default.
• W3140954637 created "2021-04-13" @default.
• W3140954637 creator A5029548952 @default.
• W3140954637 creator A5046200576 @default.
• W3140954637 creator A5053180405 @default.
• W3140954637 creator A5058548677 @default.
• W3140954637 creator A5070279379 @default.
• W3140954637 creator A5077574174 @default.
• W3140954637 creator A5080312749 @default.
• W3140954637 date "2021-07-01" @default.
• W3140954637 modified "2023-10-01" @default.
• W3140954637 title "A preliminary study on the neurotoxic mechanism of harmine in Caenorhabditis elegans" @default.
• W3140954637 cites W1652342837 @default.
• W3140954637 cites W1816421912 @default.
• W3140954637 cites W1895810840 @default.
• W3140954637 cites W1922855160 @default.
• W3140954637 cites W1958439522 @default.
• W3140954637 cites W1965822529 @default.
• W3140954637 cites W2003454094 @default.
• W3140954637 cites W2013815346 @default.
• W3140954637 cites W2042950245 @default.
• W3140954637 cites W2075838973 @default.
• W3140954637 cites W2076082769 @default.
• W3140954637 cites W2087890962 @default.
• W3140954637 cites W2141891795 @default.
• W3140954637 cites W2149941045 @default.
• W3140954637 cites W2254292298 @default.
• W3140954637 cites W2308449061 @default.
• W3140954637 cites W2336040088 @default.
• W3140954637 cites W2518002269 @default.
• W3140954637 cites W2530939851 @default.
• W3140954637 cites W2545623698 @default.
• W3140954637 cites W2582063619 @default.
• W3140954637 cites W2591096635 @default.
• W3140954637 cites W2743856193 @default.
• W3140954637 cites W2791853623 @default.
• W3140954637 cites W2797335506 @default.
• W3140954637 cites W2898050345 @default.
• W3140954637 cites W2923066724 @default.
• W3140954637 cites W2982000018 @default.
• W3140954637 cites W2990482838 @default.
• W3140954637 cites W3000598629 @default.
• W3140954637 doi "https://doi.org/10.1016/j.cbpc.2021.109038" @default.
• W3140954637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33794375" @default.
• W3140954637 hasPublicationYear "2021" @default.
• W3140954637 type Work @default.
• W3140954637 sameAs 3140954637 @default.
• W3140954637 citedByCount "7" @default.
• W3140954637 countsByYear W31409546372021 @default.
• W3140954637 countsByYear W31409546372022 @default.
• W3140954637 countsByYear W31409546372023 @default.
• W3140954637 crossrefType "journal-article" @default.
• W3140954637 hasAuthorship W3140954637A5029548952 @default.
• W3140954637 hasAuthorship W3140954637A5046200576 @default.
• W3140954637 hasAuthorship W3140954637A5053180405 @default.
• W3140954637 hasAuthorship W3140954637A5058548677 @default.
• W3140954637 hasAuthorship W3140954637A5070279379 @default.
• W3140954637 hasAuthorship W3140954637A5077574174 @default.
• W3140954637 hasAuthorship W3140954637A5080312749 @default.
• W3140954637 hasConcept C104317684 @default.
• W3140954637 hasConcept C178790620 @default.
• W3140954637 hasConcept C181199279 @default.
• W3140954637 hasConcept C185592680 @default.
• W3140954637 hasConcept C2777667214 @default.
• W3140954637 hasConcept C2778816929 @default.
• W3140954637 hasConcept C2778944004 @default.
• W3140954637 hasConcept C2779491297 @default.
• W3140954637 hasConcept C2780237542 @default.
• W3140954637 hasConcept C2780560928 @default.
• W3140954637 hasConcept C2781450507 @default.
• W3140954637 hasConcept C29730261 @default.
• W3140954637 hasConcept C33070731 @default.
• W3140954637 hasConcept C55493867 @default.
• W3140954637 hasConcept C59822182 @default.
• W3140954637 hasConcept C86803240 @default.
• W3140954637 hasConcept C98274493 @default.
• W3140954637 hasConceptScore W3140954637C104317684 @default.
• W3140954637 hasConceptScore W3140954637C178790620 @default.
• W3140954637 hasConceptScore W3140954637C181199279 @default.
• W3140954637 hasConceptScore W3140954637C185592680 @default.
• W3140954637 hasConceptScore W3140954637C2777667214 @default.
• W3140954637 hasConceptScore W3140954637C2778816929 @default.
• W3140954637 hasConceptScore W3140954637C2778944004 @default.
• W3140954637 hasConceptScore W3140954637C2779491297 @default.
• W3140954637 hasConceptScore W3140954637C2780237542 @default.
• W3140954637 hasConceptScore W3140954637C2780560928 @default.
• W3140954637 hasConceptScore W3140954637C2781450507 @default.
• W3140954637 hasConceptScore W3140954637C29730261 @default.
• W3140954637 hasConceptScore W3140954637C33070731 @default.
• W3140954637 hasConceptScore W3140954637C55493867 @default.
• W3140954637 hasConceptScore W3140954637C59822182 @default.
• W3140954637 hasConceptScore W3140954637C86803240 @default.
• W3140954637 hasConceptScore W3140954637C98274493 @default.
• W3140954637 hasFunder F4320309618 @default.
• W3140954637 hasFunder F4320322935 @default.
• W3140954637 hasLocation W31409546371 @default.
• W3140954637 hasOpenAccess W3140954637 @default.
• W3140954637 hasPrimaryLocation W31409546371 @default.

• next