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- W3140967360 startingPage "3765" @default.
- W3140967360 abstract "Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and oxygen supply to the tumor cells through the decrease of the vascular network and the avoidance of new blood vessels formation. Most of the anti-angiogenic agents approved for cancer treatment rely on targeting vascular endothelial growth factor (VEGF) actions, as VEGF signaling is considered the main angiogenesis promotor. In addition to the control of angiogenesis, these drugs can potentiate immune therapy as VEGF also exhibits immunosuppressive functions. Despite the mechanistic rational that strongly supports the benefit of drugs to stop cancer progression, they revealed to be insufficient in most cases. We hypothesize that the rehabilitation of old drugs that interfere with mechanisms of angiogenesis related to tumor microenvironment might represent a promising strategy. In this review, we deepened research on the molecular mechanisms underlying anti-angiogenic strategies and their failure and went further into the alternative mechanisms that impact angiogenesis. We concluded that the combinatory targeting of alternative effectors of angiogenic pathways might be a putative solution for anti-angiogenic therapies." @default.
- W3140967360 created "2021-04-13" @default.
- W3140967360 creator A5017135827 @default.
- W3140967360 creator A5047987801 @default.
- W3140967360 creator A5058622754 @default.
- W3140967360 creator A5076208068 @default.
- W3140967360 date "2021-04-05" @default.
- W3140967360 modified "2023-10-12" @default.
- W3140967360 title "Anti-Angiogenic Therapy: Current Challenges and Future Perspectives" @default.
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