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- W3140971027 endingPage "191" @default.
- W3140971027 startingPage "165" @default.
- W3140971027 abstract "Double-strand DNA breaks (DSBs) are the most lethal type of DNA damage, making DSB repair critical for cell survival. However, some DSB repair pathways are mutagenic and promote genome rearrangements, leading to genome destabilization. One such pathway is break-induced replication (BIR), which repairs primarily one-ended DSBs, similar to those formed by collapsed replication forks or telomere erosion. BIR is initiated by the invasion of a broken DNA end into a homologous template, synthesizes new DNA within the context of a migrating bubble, and is associated with conservative inheritance of new genetic material. This mode of synthesis is responsible for a high level of genetic instability associated with BIR. Eukaryotic BIR was initially investigated in yeast, but now it is also actively studied in mammalian systems. Additionally, a significant breakthrough has been made regarding the role of microhomology-mediated BIR in the formation of complex genomic rearrangements that underly various human pathologies." @default.
- W3140971027 created "2021-04-13" @default.
- W3140971027 creator A5010697602 @default.
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- W3140971027 creator A5033069001 @default.
- W3140971027 creator A5066202920 @default.
- W3140971027 creator A5070502223 @default.
- W3140971027 date "2021-06-20" @default.
- W3140971027 modified "2023-10-06" @default.
- W3140971027 title "Repair of DNA Breaks by Break-Induced Replication" @default.
- W3140971027 cites W1545080826 @default.
- W3140971027 cites W1562677361 @default.
- W3140971027 cites W1600373583 @default.
- W3140971027 cites W1601755300 @default.
- W3140971027 cites W1758844431 @default.
- W3140971027 cites W1790075212 @default.
- W3140971027 cites W1816802498 @default.
- W3140971027 cites W1863677123 @default.
- W3140971027 cites W1946364834 @default.
- W3140971027 cites W1964831588 @default.
- W3140971027 cites W1966346464 @default.
- W3140971027 cites W1968493165 @default.
- W3140971027 cites W1971203189 @default.
- W3140971027 cites W1972984145 @default.
- W3140971027 cites W1974573306 @default.
- W3140971027 cites W1977871027 @default.
- W3140971027 cites W1981776102 @default.
- W3140971027 cites W1982602899 @default.
- W3140971027 cites W1983228670 @default.
- W3140971027 cites W1987369038 @default.
- W3140971027 cites W2003236929 @default.
- W3140971027 cites W2007114583 @default.
- W3140971027 cites W2007325090 @default.
- W3140971027 cites W2009824854 @default.
- W3140971027 cites W2009825306 @default.
- W3140971027 cites W2012838063 @default.
- W3140971027 cites W2013073993 @default.
- W3140971027 cites W2015268864 @default.
- W3140971027 cites W2016357039 @default.
- W3140971027 cites W2020195175 @default.
- W3140971027 cites W2020991778 @default.
- W3140971027 cites W2021016692 @default.
- W3140971027 cites W2021703784 @default.
- W3140971027 cites W2021881561 @default.
- W3140971027 cites W2022682389 @default.
- W3140971027 cites W2029895295 @default.
- W3140971027 cites W2034979835 @default.
- W3140971027 cites W2035931727 @default.
- W3140971027 cites W2038462200 @default.
- W3140971027 cites W2043028465 @default.
- W3140971027 cites W2052003635 @default.
- W3140971027 cites W2052202220 @default.
- W3140971027 cites W2054560592 @default.
- W3140971027 cites W2054621069 @default.
- W3140971027 cites W2056657560 @default.
- W3140971027 cites W2059885034 @default.
- W3140971027 cites W2060955969 @default.
- W3140971027 cites W2064728219 @default.
- W3140971027 cites W2066899264 @default.
- W3140971027 cites W2067573570 @default.
- W3140971027 cites W2069367380 @default.
- W3140971027 cites W2069839388 @default.
- W3140971027 cites W2075478564 @default.
- W3140971027 cites W2077570881 @default.
- W3140971027 cites W2082619072 @default.
- W3140971027 cites W2083344047 @default.
- W3140971027 cites W2086881223 @default.
- W3140971027 cites W2087623507 @default.
- W3140971027 cites W2088502483 @default.
- W3140971027 cites W2090447055 @default.
- W3140971027 cites W2097124161 @default.
- W3140971027 cites W2102027852 @default.
- W3140971027 cites W2104154956 @default.
- W3140971027 cites W2104493050 @default.
- W3140971027 cites W2109541017 @default.
- W3140971027 cites W2109948920 @default.
- W3140971027 cites W2110977400 @default.
- W3140971027 cites W2113908436 @default.
- W3140971027 cites W2115369480 @default.
- W3140971027 cites W2117265134 @default.
- W3140971027 cites W2118991749 @default.
- W3140971027 cites W2120204689 @default.
- W3140971027 cites W2120267381 @default.
- W3140971027 cites W2121942815 @default.
- W3140971027 cites W2124242199 @default.
- W3140971027 cites W2125718353 @default.
- W3140971027 cites W2126552646 @default.
- W3140971027 cites W2127663205 @default.
- W3140971027 cites W2129755545 @default.
- W3140971027 cites W2131666315 @default.
- W3140971027 cites W2133744934 @default.
- W3140971027 cites W2134767616 @default.
- W3140971027 cites W2136232605 @default.
- W3140971027 cites W2137191431 @default.
- W3140971027 cites W2141288561 @default.
- W3140971027 cites W2144550200 @default.
- W3140971027 cites W2144839130 @default.
- W3140971027 cites W2147429782 @default.