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- W3140971574 abstract "Abstract Background: The transcriptional co-activator with PDZ-binding motif(TAZ) and Yes-associated protein(YAP) are well-known members of the Hippo signaling pathway, which may correlated with organ development regulation and interaction between organ and tumor. At the same time, it is closely related to the occurrence and development of tumors. Methods: The purpose of this study is to explore a potential marker that is specific for gastric cancer. In our study, we designed a bioinformatics analysis of the clinicopathological features of TAZ and YAP mRNA expression in gastric cancer using Kaplan-Meier plotter, Oncomine and TCGA databases. Results: According to Kaplan-Meier plotter, the mRNA expression of TAZ and YAP are negatively related with the overall post-progression and first progression survival rates of gastric cancer patients(p＜0.05), even stratified by clinicopathological features(p＜0.05). As shown in Oncomine, TAZ and YAP mRNA expression is higher in gastric cancers than gastric tissue and gastric mucosa(p＜0.05). In TCGA data, univariate analysis showed that age, TNM staging, lymph node metastasis, distant metastasis was correlated with prognosis in patients with gastric cancer(p＜0.05). COX multivariate analysis showed that age and distant metastasis are risk factors affecting the survival of patients with gastric cancer(p＜0.05). Conclusion: TAZ/YAP may be employed as a good molecular market for patients and might help researchers discover a targeted inhibitor for treating gastric cancer." @default.
- W3140971574 created "2021-04-13" @default.
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- W3140971574 date "2020-03-17" @default.
- W3140971574 modified "2023-09-25" @default.
- W3140971574 title "The clinicopathological and prognostic values of TAZ and YAP expression in gastric cancer" @default.
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- W3140971574 doi "https://doi.org/10.21203/rs.3.rs-17406/v1" @default.
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