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- W3140986871 abstract "P ~ c H , G., REIFFENSTBIN, R. I., and UNKEEBAGH, .-D. 1990. Application of the isobologram technique for the analysis s f combined effects with respect to additivity as wdl as independence. Can. J. Bhysiol. Pharmacol. 68: 682-688. Combined actions of two substances with similar effects are frequently expressed by pairs of doses that produce a fixed response, usually 50%, in so-called isobolograms (ED5o isobolograms). In addition to the dose scales in such graphs we propose the addition of effect scdes, where possible, to indicate the effect at certain doses, e.g., the ED,,. We further propose to construct isoboles for expected independent interaction, in addition to the additivity line, for which purpose a simple procedure is delineated. In practice, an independent isobole for 58% effect passes through the point formed by the EB,,s of A and of B in ED,, isobolograms. Thus, the ED,,s constitute the zenith of an independent isobole in ED,, isobolsgram. It is shown that theoretical independent isoboles can either represent additive, overadditive, or underadditive interactions, depending on the steepness sf the dose-response curves of the components. Hence, dmgs with shallow dose-response curves exhibit overadditive independent effects, compounds with exponentially steep curves show additive independent interactions. Substances with very steep dose response curves, producing lethal effects, exhibited marked deraHcHitive effects which could be ascribed largely to an independent mechanism of action of the components. Hence, the inclusion of independent isoboles into conventional isobolograms provides new insights into the mechanisms of interactions and into the actions of the components. Interactions can thus be characterized better and more completely, and misinterpretatibns appear less likely than with conventional isoboles. Key word$: isobolograms, method, effect scales, independence." @default.
- W3140986871 created "2021-04-13" @default.
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- W3140986871 date "2007-01-01" @default.
- W3140986871 modified "2023-09-27" @default.
- W3140986871 title "Application of the isobologram technique for the analysis of combined effects with respect to additivity as well as independence" @default.
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