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- W3140992026 abstract "目的 在Ⅱ期临床试验初步有效基础上,进一步验证人尿激肽原酶治疗急性脑梗死的有效性和安全性.方法 多中心随机双盲安慰剂3∶1平行对照设计;起病48 h内急性脑梗死患者为入选对象;剂量为0.15 PANU/d慢速静脉点滴,共3周.结果 共入组466例,完成意向治疗数据集分析的446例,其中治疗组330例,对照组116例.治疗前两组基线差异无统计学意义.治疗1周时,治疗组欧洲卒中量表(ESS)增分率已优于对照组;3周时治疗组ESS较治疗前增加55.1%±33.0%,而对照组增加44.7%±32.8%,P=0.0022;等级疗效有效率治疗组为71.21%,对照组为52.59%,两组比较,Fisher确切概率P=0.0004.3个月回访者374例,治疗组(280例)中Barthel指数≥50者高于对照组(94例),P=0.0228.与试验药物肯定有关或可能有关的不良反应发生率为7.74%.4例严重不良反应,其中2例死亡,但判定与研究药物无关;另2例发生血压突然下降,考虑与合用血管紧张素转换酶抑制剂和尤瑞克林滴速过快有关,及时给予升压药物后,血压很快回升,未留不良后果.其他不良反应有恶心呕吐、胸闷心慌、头胀痛、脸潮红、心悸等,程度较轻,多数无需特殊处理.结论 尤瑞克林能有效地改善急性脑梗死的神经功能缺损." @default.
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