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- W3141007441 abstract "Objective To evaluate the clinical efficacy of dihydroartemisinin—mefloquine on acute uncomplicated falciparum malaria. Methods Fifty-four patients with symptomatic falciparum malaria were allocated to receive oral dihydroartemisinin at a single dose of 120*!mg on day 1, followed by mefloquine, 750*!mg and 500*!mg on days 2 and 3, respectively. Follow-up was performed on days 1,2,3,4,7,14,21, and 28. Results All patients had a rapid initial response to treatment. The parasite clearance time (PCT) after treatment was 30.7±3.6 hours. The fever subsidence time (FST) after treatment was 21.2±2.8 hours. Two patients had a recrudescence 21 and 25 days respectively after the disappearance of parasitemia, hence the recrudescence rate was 3.7% and the cure rate was 96.3%. No serious adverse effects were observed, only mild and transient nausea, vomiting and loss of appetite. Conclusion A combination of dihydroartemisinin and mefloquine is effective in the treatment of acute uncomplicated falciparum malaria." @default.
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- W3141007441 date "2001-01-01" @default.
- W3141007441 modified "2023-09-24" @default.
- W3141007441 title "Efficacy of dihydroartemisinin-mefloquine on acute uncomplicated falciparum malaria" @default.
- W3141007441 hasPublicationYear "2001" @default.
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