FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3141020283> ?p ?o ?g. }

• W3141020283 endingPage "4325" @default.
• W3141020283 startingPage "4316" @default.
• W3141020283 abstract "Abstract Uromodulin (UMOD) can bind complement factor H (cFH) and inhibit the activation of complement alternative pathway (AP) by enhancing the cofactor activity of cFH on degeneration of C3b. UMOD, an N‐glycans‐rich glycoprotein, is expressed in thick ascending limb of Henle's loop where the epithelia need to adapt to gradient change of pH and ion concentration. ELISA‐based cofactor activity of cFH and erythrocytes haemolytic assay was used to measure the impact of native and de‐glycosylated UMOD on the functions of cFH. The binding assay was performed under different pH and ion concentrations, using ELISA. The levels of sialic acid on UMOD, from healthy controls and patients with chronic kidney disease (CKD), were also detected by lectin‐ELISA. It was shown that removal of glycans decreased the binding between UMOD and cFH and abolished the ability of enhancing C3b degradation. In acidic condition, the binding became stronger, but it reduced as sodium concentration increased. A significant decrease of α‐2,3 sialic acids on UMOD was observed in CKD patients compared with that of healthy individuals. The sialic acids on UMOD, local pH and sodium concentration could impact the binding capacity between UMOD and cFH and thus regulate the activation of complement AP." @default.
• W3141020283 created "2021-04-13" @default.
• W3141020283 creator A5008236609 @default.
• W3141020283 creator A5008288787 @default.
• W3141020283 creator A5009651395 @default.
• W3141020283 creator A5021719486 @default.
• W3141020283 creator A5061547016 @default.
• W3141020283 creator A5085971155 @default.
• W3141020283 creator A5090728786 @default.
• W3141020283 date "2021-03-31" @default.
• W3141020283 modified "2023-09-23" @default.
• W3141020283 title "The importance of sialic acid, pH and ion concentration on the interaction of uromodulin and complement factor H" @default.
• W3141020283 cites W1529745308 @default.
• W3141020283 cites W1580018685 @default.
• W3141020283 cites W1850950958 @default.
• W3141020283 cites W1898513650 @default.
• W3141020283 cites W1934569129 @default.
• W3141020283 cites W1967490910 @default.
• W3141020283 cites W1970276449 @default.
• W3141020283 cites W1974269325 @default.
• W3141020283 cites W1985498833 @default.
• W3141020283 cites W1985804040 @default.
• W3141020283 cites W1986055029 @default.
• W3141020283 cites W1989222495 @default.
• W3141020283 cites W1991746229 @default.
• W3141020283 cites W1995383525 @default.
• W3141020283 cites W2001124618 @default.
• W3141020283 cites W2014755416 @default.
• W3141020283 cites W2022548242 @default.
• W3141020283 cites W2033824371 @default.
• W3141020283 cites W2051966519 @default.
• W3141020283 cites W2052431369 @default.
• W3141020283 cites W2056609174 @default.
• W3141020283 cites W2073745575 @default.
• W3141020283 cites W2073775604 @default.
• W3141020283 cites W2077782829 @default.
• W3141020283 cites W2091338738 @default.
• W3141020283 cites W2101547223 @default.
• W3141020283 cites W2108629029 @default.
• W3141020283 cites W2113181839 @default.
• W3141020283 cites W2135400491 @default.
• W3141020283 cites W2137321379 @default.
• W3141020283 cites W2144043457 @default.
• W3141020283 cites W2149129145 @default.
• W3141020283 cites W2153956648 @default.
• W3141020283 cites W2165144969 @default.
• W3141020283 cites W225287866 @default.
• W3141020283 cites W2287695126 @default.
• W3141020283 cites W2336097720 @default.
• W3141020283 cites W2344843858 @default.
• W3141020283 cites W2560499646 @default.
• W3141020283 cites W2738968991 @default.
• W3141020283 cites W2770745992 @default.
• W3141020283 cites W2884428534 @default.
• W3141020283 cites W2888657268 @default.
• W3141020283 cites W2979790134 @default.
• W3141020283 cites W3006014093 @default.
• W3141020283 cites W302025023 @default.
• W3141020283 cites W4229508150 @default.
• W3141020283 doi "https://doi.org/10.1111/jcmm.16492" @default.
• W3141020283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8093974" @default.
• W3141020283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33788378" @default.
• W3141020283 hasPublicationYear "2021" @default.
• W3141020283 type Work @default.
• W3141020283 sameAs 3141020283 @default.
• W3141020283 citedByCount "3" @default.
• W3141020283 countsByYear W31410202832022 @default.
• W3141020283 countsByYear W31410202832023 @default.
• W3141020283 crossrefType "journal-article" @default.
• W3141020283 hasAuthorship W3141020283A5008236609 @default.
• W3141020283 hasAuthorship W3141020283A5008288787 @default.
• W3141020283 hasAuthorship W3141020283A5009651395 @default.
• W3141020283 hasAuthorship W3141020283A5021719486 @default.
• W3141020283 hasAuthorship W3141020283A5061547016 @default.
• W3141020283 hasAuthorship W3141020283A5085971155 @default.
• W3141020283 hasAuthorship W3141020283A5090728786 @default.
• W3141020283 hasBestOaLocation W31410202832 @default.
• W3141020283 hasConcept C108625454 @default.
• W3141020283 hasConcept C111684460 @default.
• W3141020283 hasConcept C14356644 @default.
• W3141020283 hasConcept C185592680 @default.
• W3141020283 hasConcept C189446657 @default.
• W3141020283 hasConcept C203014093 @default.
• W3141020283 hasConcept C2780026642 @default.
• W3141020283 hasConcept C2780115458 @default.
• W3141020283 hasConcept C2780758401 @default.
• W3141020283 hasConcept C55493867 @default.
• W3141020283 hasConcept C74460091 @default.
• W3141020283 hasConcept C86803240 @default.
• W3141020283 hasConcept C8891405 @default.
• W3141020283 hasConceptScore W3141020283C108625454 @default.
• W3141020283 hasConceptScore W3141020283C111684460 @default.
• W3141020283 hasConceptScore W3141020283C14356644 @default.
• W3141020283 hasConceptScore W3141020283C185592680 @default.
• W3141020283 hasConceptScore W3141020283C189446657 @default.
• W3141020283 hasConceptScore W3141020283C203014093 @default.
• W3141020283 hasConceptScore W3141020283C2780026642 @default.
• W3141020283 hasConceptScore W3141020283C2780115458 @default.

• next