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• W3141028540 abstract "The novel fluorescent agonists were discovered herein for α1-adrenergic receptors (α1-ARs) based on photoinduced electron transfer (PeT) off-on switch by conjugating the fluorophore 7-(diethylamino)coumarin-3-carboxylic acid with phenylephrine. After careful evaluation, these probes exhibited efficient binding affinity with α1-ARs and could be applied to selectively imaging α1-ARs or successfully tracing the dynamic process of α1-AR internalization in living cells. Meanwhile, a bioluminescence resonance energy transfer binding assay with these new probes has been well-established and applied. Therefore, these PeT-based on-off agonists may serve as powerful tools for the α1-AR-associated study during drug discovery." @default.
• W3141028540 created "2021-04-13" @default.
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• W3141028540 date "2021-04-08" @default.
• W3141028540 modified "2023-10-15" @default.
• W3141028540 title "Photoinduced Electron Transfer-Based Fluorescent Agonists for α₁-Adrenergic Receptors Imaging" @default.
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• W3141028540 doi "https://doi.org/10.1021/acs.analchem.0c03841" @default.
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