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- W3141037653 abstract "AIM:To study the effects of tetrandrine (Tet) and chlorpromazine (Chl) on synthesis of collagen and hyaluronic acid (HA) in cultured human lung fibroblasts (HLF). METHODS: The synthesis of collagen and HA was assessed by measuring the incorporation of [3H]proline and radioimmunoassay. RESULTS: Both Tet (5-80 μmol L-1) and Chl (10-40 μmol L-1) diminished the collagen synthesis in a concentration-dependent manner. The suppression was aggravated at 36 - 48 h. The HA content in the supernatant of culture also decreased gradually with the increasing dosage of Tet or Chl after 24-h exposure. There was no obvious toxic effect of Tet on HLF cells at 5-20 μmol L-1. CONCLUSION:Tet 5-20μmol L-1 decreased the production of collagen and HA without obvious toxity on HLF,suggesting that Tet could be a hopeful anti-fibrosis drug." @default.
- W3141037653 created "2021-04-13" @default.
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- W3141037653 date "1995-01-01" @default.
- W3141037653 modified "2023-09-25" @default.
- W3141037653 title "Effects of tetrandrine and chlorpromazine on synthesis of collagen and hyaluronic acid in cultured human lung fibroblasts" @default.
- W3141037653 hasPublicationYear "1995" @default.
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