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- W3141092126 abstract "Objective To study the correlation of gene polymorphism IL-1B+3953and TNF-Α-308and the genetic susceptibility to moderate-to-advanced adult periodontitis(AP).Methods PCR-RFLP technique was used to identify IL-1B+3953and TNF-Α-308genotype.Multivariate logistic regression model was utilized to assess the relationship of IL-1B+3953and TNF-Α-308positive genotype to disease status while adjusting for other potential confounders.Results The frequency of IL-1B+3953(28.23%)and TNF-Α-308(29.03%)allele2positive genotype in patients with moderate-to-advanced AP showed a statistically significant increase compared to the control group frequency(13.95%IL-1B+3953and11.05%TNF-Α-308),and the difference was of much significance(P0.01in both group).Multivariate logistic regression analysis showed that IL-1B+3953and TNF-Α-308allele2positive genotype may increase the odds of having moderate-to-advanced AP and the IL-1B+3953(P0.05)and TNF-Α-308(P0.01)allele2positive genotype was of statistical significance.Conclusions IL-1B+3953and TNF-Α-308allele2positive genotype have closer correlation with moderate-to-advanced AP." @default.
- W3141092126 created "2021-04-13" @default.
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- W3141092126 date "2003-01-01" @default.
- W3141092126 modified "2023-09-24" @default.
- W3141092126 title "Study on the Correlation of Cytokine Gene Polymorphism with Chronic Periodontitis" @default.
- W3141092126 hasPublicationYear "2003" @default.
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