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• W314113 abstract "Transplantation of liver stem/progenitor cells offers a new approach for treating genetic diseases or liver failure. Transplantation of mature liver cells or whole liver is limited by severe shortages of donor organs. Extensive studies indicate that optimal function of transplanted cells may require cell transplantation into the liver itself rather than into ectopic sites. Cells may be transplanted into the liver by intraportal or intrasplenic injection, which leads to the entry of transplanted cells in liver sinusoids, and eventually transplanted cells become incorporated in the liver parenchyma. During this process, transplanted cells disrupt sinusoidal endothelial cells to enter the liver plate and reestablish plasma membrane structures by joining with native liver cells. Some liver progenitor cells (LPCs) are less able to integrate and may remain within the vascular spaces. Approximately 1 to 2% of the normal liver can be repopulated in animals when a somewhat larger cell number is transplanted. However, donor hepatocytes can eventually replace virtually the entire liver of animals, if transplanted cells are spared from disease processes that threaten the survival of native hepatocytes. In fact, in FAH mice with chronic liver injury owing to extensive tyrosinemia, normal adult hepatocytes have been demonstrated to divide more than seven times each, as they repopulate the liver. Extensive repopulation will also occur in recipient animals treated with hepatotoxic chemicals, such as retrorsine in rats, which damages and inhibits proliferation of native hepatocytes. Putative LPCs in the form of oval cells produced following some types of liver injury may differentiate into hepatocytes after transplantation. Similarly, putative oval cell lines and a hepatoblast cell line derived from the embryonic mouse liver may differentiate into hepatocytes and additional cell types. Primary cells isolated from the fetal rat liver and the fetal human liver can differentiate into mature hepatocytes in animals. Finally, cells from even other organs, especially the bone marrow, can differentiate into hepatocytes after transplantation into animals. Liver cell transplantation has been used to correct a number of metabolic diseases in experimental animals and cell therapy shows enormous potential. Use of liver stem/ progenitor cells will thus be applicable for cell therapy in multiple human diseases, and further efforts in this area will b" @default.
• W314113 created "2016-06-24" @default.
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• W314113 date "2004-01-01" @default.
• W314113 modified "2023-09-23" @default.
• W314113 title "Transplantation of Hepatic Stem Cells and Potential Applications for Cell Therapy" @default.
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• W314113 doi "https://doi.org/10.1007/978-1-59259-411-5_36" @default.
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