Matches in SemOpenAlex for { <https://semopenalex.org/work/W314115991> ?p ?o ?g. }
- W314115991 endingPage "28" @default.
- W314115991 startingPage "19" @default.
- W314115991 abstract "Leptin (Lep) is emerging as a pivotal molecule involved in both the early events and the terminal phases of Alzheimer's disease (AD). In the canonical pathway, Lep acts as an anorexigenic factor via its effects on hypothalamic nucleus. However, additional functions of Lep in the hippocampus and cortex have been unravelled in recent years. Early events in the sporadic form of AD likely involve cellular level alterations which can have an effect on food intake and metabolism. Thus, AD can be conceivably interpreted as a multiorgan pathology that not only results in a dramatic neuronal loss in brain areas such as the hippocampus and the cortex (ultimately leading to a significant cognitive impairment) but as a disease which also affects body-weight homeostasis. According to this view, body-weight control disruptions are to be expected in both the early- and late-stage AD, concomitant with changes in serum Lep content, alterations in Lep transport across the blood-brain barrier (BBB) and Lep receptor-related signalling abnormalities. Lep is a member of the adipokine family of molecules, while the Lep receptor belongs to the class I cytokine receptors. Since cellular response to adipokine signalling can be either potentiated or diminished as a result of specific ligand-receptor interactions, Lep interactions with other members of the adipokine family including amylin, ghrelin and hormones such as prolactin require further investigation. In this review, we provide a general perspective on the functions of Lep in the brain, with a particular focus on the sporadic AD." @default.
- W314115991 created "2016-06-24" @default.
- W314115991 creator A5007454609 @default.
- W314115991 creator A5007470653 @default.
- W314115991 creator A5021585723 @default.
- W314115991 creator A5045978725 @default.
- W314115991 creator A5054837237 @default.
- W314115991 creator A5056796479 @default.
- W314115991 creator A5063929424 @default.
- W314115991 creator A5064856501 @default.
- W314115991 creator A5073770071 @default.
- W314115991 creator A5080353994 @default.
- W314115991 date "2015-11-01" @default.
- W314115991 modified "2023-10-18" @default.
- W314115991 title "The role of leptin in the sporadic form of Alzheimer's disease. Interactions with the adipokines amylin, ghrelin and the pituitary hormone prolactin" @default.
- W314115991 cites W102714011 @default.
- W314115991 cites W1501107256 @default.
- W314115991 cites W1513985839 @default.
- W314115991 cites W1520100911 @default.
- W314115991 cites W1589706085 @default.
- W314115991 cites W1607160372 @default.
- W314115991 cites W1607364459 @default.
- W314115991 cites W1616806865 @default.
- W314115991 cites W1676341163 @default.
- W314115991 cites W1942085067 @default.
- W314115991 cites W1964562779 @default.
- W314115991 cites W1966546615 @default.
- W314115991 cites W1967041839 @default.
- W314115991 cites W1968531410 @default.
- W314115991 cites W1972171905 @default.
- W314115991 cites W1972430217 @default.
- W314115991 cites W1973024955 @default.
- W314115991 cites W1973741963 @default.
- W314115991 cites W1979858170 @default.
- W314115991 cites W1980539694 @default.
- W314115991 cites W1981514736 @default.
- W314115991 cites W1981637093 @default.
- W314115991 cites W1983000029 @default.
- W314115991 cites W1983271977 @default.
- W314115991 cites W1987478242 @default.
- W314115991 cites W1989136084 @default.
- W314115991 cites W1989298035 @default.
- W314115991 cites W1989703960 @default.
- W314115991 cites W1992423721 @default.
- W314115991 cites W1994056464 @default.
- W314115991 cites W1994871918 @default.
- W314115991 cites W1994922654 @default.
- W314115991 cites W1995144868 @default.
- W314115991 cites W1996713062 @default.
- W314115991 cites W1998319637 @default.
- W314115991 cites W1998589563 @default.
- W314115991 cites W1999851917 @default.
- W314115991 cites W2000055244 @default.
- W314115991 cites W2000437193 @default.
- W314115991 cites W2002209256 @default.
- W314115991 cites W2004135052 @default.
- W314115991 cites W2005166222 @default.
- W314115991 cites W2005519734 @default.
- W314115991 cites W2005719973 @default.
- W314115991 cites W2006181807 @default.
- W314115991 cites W2006800217 @default.
- W314115991 cites W2016115970 @default.
- W314115991 cites W2017423317 @default.
- W314115991 cites W2022388884 @default.
- W314115991 cites W2026200282 @default.
- W314115991 cites W2027963861 @default.
- W314115991 cites W2028495157 @default.
- W314115991 cites W2028720966 @default.
- W314115991 cites W2030845247 @default.
- W314115991 cites W2032324230 @default.
- W314115991 cites W2033242795 @default.
- W314115991 cites W2036874123 @default.
- W314115991 cites W2037631372 @default.
- W314115991 cites W2038003980 @default.
- W314115991 cites W2042350426 @default.
- W314115991 cites W2044185435 @default.
- W314115991 cites W2044832776 @default.
- W314115991 cites W2044937548 @default.
- W314115991 cites W2047972989 @default.
- W314115991 cites W2048151333 @default.
- W314115991 cites W2049971830 @default.
- W314115991 cites W2053680491 @default.
- W314115991 cites W2053998363 @default.
- W314115991 cites W2054986300 @default.
- W314115991 cites W2055523148 @default.
- W314115991 cites W2059124041 @default.
- W314115991 cites W2060815411 @default.
- W314115991 cites W2061655311 @default.
- W314115991 cites W2067875627 @default.
- W314115991 cites W2068769790 @default.
- W314115991 cites W2068942754 @default.
- W314115991 cites W2070740941 @default.
- W314115991 cites W2071992832 @default.
- W314115991 cites W2075453627 @default.
- W314115991 cites W2076132943 @default.
- W314115991 cites W2077645437 @default.
- W314115991 cites W2079861976 @default.
- W314115991 cites W2082997471 @default.