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- W3141262701 abstract "Assessing the self-peptides presented by susceptible major histocompatibility complex (MHC) molecules is crucial for evaluating the pathogenesis and therapeutics of tissue-specific autoimmune diseases. However, direct examination of such MHC-bound peptides displayed in the target organ remains largely impractical. Here, we demonstrate that the blood leukocytes from the nonobese diabetic (NOD) mice presented peptide epitopes to autoreactive CD4 T cells. These peptides were bound to the autoimmune class II MHC molecule (MHC-II) I-Ag7 and originated from insulin B-chain and C-peptide. The presentation required a glucose challenge, which stimulated the release of the insulin peptides from the pancreatic islets. The circulating leukocytes, especially the B cells, promptly captured and presented these peptides. Mass spectrometry analysis of the leukocyte MHC-II peptidome revealed a series of β cell–derived peptides, with identical sequences to those previously identified in the islet MHC-II peptidome. Thus, the blood leukocyte peptidome echoes that found in islets and serves to identify immunogenic peptides in an otherwise inaccessible tissue." @default.
- W3141262701 created "2021-04-13" @default.
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- W3141262701 date "2021-04-06" @default.
- W3141262701 modified "2023-10-14" @default.
- W3141262701 title "Blood leukocytes recapitulate diabetogenic peptide–MHC-II complexes displayed in the pancreatic islets" @default.
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- W3141262701 doi "https://doi.org/10.1084/jem.20202530" @default.
- W3141262701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8034384" @default.
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