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- W3141309752 abstract "天 theophylline (16 mg/kg ) 口头上地被管理在 BC 或盐的处理以后的一个小时。血样品在从有 BC 的兔子的边缘的耳朵 vein.ResultsThe 预告的处理的间隔( 0.5 , 1 , 1.5 , 2 , 3 , 4 , 6 , 8 , 12 , 24 和 36 h )导致了最大的血集中的重要增加的不同时间被撤退,在集中时间侧面曲线下面山峰集中和区域预定直到分别地是大约41.32%,35.71%和15.03%的最后一观察。当在清理,分发的体积,和半衰期的减少被观察时。BC 预告的处理减少,这被建议导致的 CYP1A 新陈代谢的活动在 bioavailability 增加并且在 theophylline 的口头的清理减少,它可能由于 CYP1A.ConclusionBC 的抑制能显著地由于 CYP1A 和 P-glycoprotein 活动的抑制可能在 vivo 改变 theophylline pharmacokinetics。把结果基于这些,当与 CYP1A 管理 BC 时,措施应该被行使底层。" @default.
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- W3141309752 date "2015-01-01" @default.
- W3141309752 modified "2023-09-23" @default.
- W3141309752 title "Pharmacokinetic interaction of Acacia catechu with CYP1A substrate theophylline in rabbits" @default.
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