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- W3141352975 abstract "Many reports have showed that bound water was involved in the interaction between/among the macromolecules. However, it has not been reported whether bound water is also involved in the binding of transfactors and ciselements in the regulation of the eukaryotic gene transcription or not. Preliminary studies have been made on the effect of bound water on the binding of estrogen receptor with estrogen responsive element in vitro. In the gel retardation assay using the cytosol extract of rat uterus as the supplier of estrogen receptor and 32 bp oligonucleotide containing a concensus vitellogenin A2 ERE as the probe, various cosolvents, such as glycerol, sucrose, Ndimethylformamide and dimethylsulfoxide, were added respectively to the reaction mixture in varying concentrations to regulate the osmotic pressure. The results indicated that the binding of ERERE was enhanced with the increase in the final concentration of these individual cosolvents. On the other hand, when the reaction was carried out under an increasing hydrostatic pressure, the ERERE binding was decreased sharply. After decompression the binding of ERERE was gradually restored to the normal level with the lapse of time. These results suggested that bound water was directly involved in the binding of ERERE and may play an important role in the regulation of the eukaryotic gene transcription." @default.
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- W3141352975 date "1998-01-01" @default.
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- W3141352975 title "Participation of Water in the Binding of Estrogen Receptor with Estrogen Responsive Element in vitro" @default.
- W3141352975 hasPublicationYear "1998" @default.
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