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• W3141353144 endingPage "108633" @default.
• W3141353144 startingPage "108633" @default.
• W3141353144 abstract "The liver is a critical mediator of lipid and/or glucose homeostasis and is a primary organ involved in dynamic changes during feeding and fasting. Additionally, hepatic-centric pathways are prone to dysregulation during pathophysiological states including metabolic syndrome (MetS) and non-alcoholic fatty liver disease. Omics platforms and GWAS have elucidated genes related to increased risk of developing MetS and related disorders, but mutations in these metabolism-related genes are rare and cannot fully explain the increasing prevalence of MetS-related pathologies worldwide. Complex interactions between diet, lifestyle, environmental factors, and genetic predisposition jointly determine inter-individual variability of disease risk. Given the complexity of these interactions, researchers have focused on master regulators of metabolic responses incorporating and mediating the impact of multiple environmental cues. Transcription factors are DNA binding, terminal executors of signaling pathways that modulate the cellular responses to complex metabolic stimuli and are related to the control of hepatic lipid and glucose homeostasis. Among numerous hepatic transcription factors involved in regulating metabolism, three emerge as key players in transducing nutrient sensing, which are dysregulated in MetS-related perturbations in both clinical and preclinical studies: cAMP Responsive Element Binding Protein 3 Like 3 (CREB3L3), Peroxisome Proliferator Activated Receptor Alpha (PPAR), and Forkhead Box O1 (FOXO1). Additionally, these three transcription factors appear to be amenable to dietary and/or nutrient-based therapies, being potential targets of nutritional therapy. In this review we aim to describe the activation, regulation, and impact of these transcription factors in the context of metabolic homeostasis. We also summarize their perspectives in MetS and nutritional therapies." @default.
• W3141353144 created "2021-04-13" @default.
• W3141353144 creator A5016291035 @default.
• W3141353144 creator A5033084741 @default.
• W3141353144 creator A5040942461 @default.
• W3141353144 creator A5048206421 @default.
• W3141353144 creator A5081879708 @default.
• W3141353144 date "2021-09-01" @default.
• W3141353144 modified "2023-10-15" @default.
• W3141353144 title "The transcription factors CREBH, PPARa, and FOXO1 as critical hepatic mediators of diet-induced metabolic dysregulation" @default.
• W3141353144 cites W1077335472 @default.
• W3141353144 cites W1503760388 @default.
• W3141353144 cites W1545747221 @default.
• W3141353144 cites W1583767403 @default.
• W3141353144 cites W1631908837 @default.
• W3141353144 cites W1637575980 @default.
• W3141353144 cites W1697594889 @default.
• W3141353144 cites W1963533730 @default.
• W3141353144 cites W1964485410 @default.
• W3141353144 cites W1965159134 @default.
• W3141353144 cites W1967972402 @default.
• W3141353144 cites W1970225752 @default.
• W3141353144 cites W1970471141 @default.
• W3141353144 cites W197267951 @default.
• W3141353144 cites W1972744939 @default.
• W3141353144 cites W1973180301 @default.
• W3141353144 cites W1973352306 @default.
• W3141353144 cites W1975022233 @default.
• W3141353144 cites W1975462549 @default.
• W3141353144 cites W1975815570 @default.
• W3141353144 cites W1975962309 @default.
• W3141353144 cites W1976050844 @default.
• W3141353144 cites W1977666051 @default.
• W3141353144 cites W1978805605 @default.
• W3141353144 cites W1979252938 @default.
• W3141353144 cites W1980338363 @default.
• W3141353144 cites W1980592590 @default.
• W3141353144 cites W1983979097 @default.
• W3141353144 cites W1987734980 @default.
• W3141353144 cites W1988805205 @default.
• W3141353144 cites W1990640778 @default.
• W3141353144 cites W1994036484 @default.
• W3141353144 cites W1996200651 @default.
• W3141353144 cites W1998323589 @default.
• W3141353144 cites W2000962819 @default.
• W3141353144 cites W2001738812 @default.
• W3141353144 cites W2001938126 @default.
• W3141353144 cites W2002959397 @default.
• W3141353144 cites W2004454505 @default.
• W3141353144 cites W2005251376 @default.
• W3141353144 cites W2006574739 @default.
• W3141353144 cites W2006838809 @default.
• W3141353144 cites W2007582789 @default.
• W3141353144 cites W2009010832 @default.
• W3141353144 cites W2012340790 @default.
• W3141353144 cites W2014146744 @default.
• W3141353144 cites W2015721847 @default.
• W3141353144 cites W2017168923 @default.
• W3141353144 cites W2018330529 @default.
• W3141353144 cites W2019486401 @default.
• W3141353144 cites W2023394218 @default.
• W3141353144 cites W2023597944 @default.
• W3141353144 cites W2023789187 @default.
• W3141353144 cites W2025658684 @default.
• W3141353144 cites W2029729619 @default.
• W3141353144 cites W2031889049 @default.
• W3141353144 cites W2032261439 @default.
• W3141353144 cites W2032427485 @default.
• W3141353144 cites W2033029728 @default.
• W3141353144 cites W2033208645 @default.
• W3141353144 cites W2033245528 @default.
• W3141353144 cites W2035210330 @default.
• W3141353144 cites W2036409621 @default.
• W3141353144 cites W2036837630 @default.
• W3141353144 cites W2037341437 @default.
• W3141353144 cites W2041950645 @default.
• W3141353144 cites W2042497914 @default.
• W3141353144 cites W2042881415 @default.
• W3141353144 cites W2045497589 @default.
• W3141353144 cites W2046732903 @default.
• W3141353144 cites W2052931002 @default.
• W3141353144 cites W2053972428 @default.
• W3141353144 cites W2056085420 @default.
• W3141353144 cites W2056677650 @default.
• W3141353144 cites W2057247058 @default.
• W3141353144 cites W2062629127 @default.
• W3141353144 cites W2067740038 @default.
• W3141353144 cites W2067969345 @default.
• W3141353144 cites W2072362233 @default.
• W3141353144 cites W2073663250 @default.
• W3141353144 cites W2073846766 @default.
• W3141353144 cites W2075137629 @default.
• W3141353144 cites W2075385622 @default.
• W3141353144 cites W2076103389 @default.
• W3141353144 cites W2078434599 @default.
• W3141353144 cites W2080036080 @default.
• W3141353144 cites W2080361134 @default.
• W3141353144 cites W2080831128 @default.

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