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- W3141453396 abstract "把烟碱的醋胆素受体(nAChRs ) 基于形成功能的 neuronal 的五个子单元的作文，他们被组织进任何一个 heteromeric (包括伪和尾子单元) 或 homomeric (包括的仅仅伪子单元) 受体。nAChRs 被知道是对钙离子可渗透的差别，与有到钙的最高的渗透之一的伪 7 nAChR 子类型。通过 nAChRs 的钙流入，特别地通过伪 -bungarotoxin 敏感的伪 7 包含 nAChRs，是提起细胞质的钙层次的一个很有效的方法。nAChRs 的激活能调停细胞质的钙信号的三种类型：( 1 )通过 nAChRs 指导钙流入，( 2 )通过被 调停nAChR 的去极激活的电压依赖者钙隧道( VDCC )的间接的钙流入，并且( 3 )导致钙的钙版本( CICR )(由开始的二来源被触发)从 endoplasmic 蜂窝胃(嗯)通过 ryanodine 受体和肌醇( 1,4,5 ) -triphosphate 受体( IP3Rs )。下游的发信号事件由 调停nAChR 的钙回答调停了能被组织进即时效果(例如 neurotransmitter 版本，能在 nAChR 激活以后发生在毫秒，短期的效果(例如 nAChR 的恢复，通过细胞的发信号的不敏感性串联)，并且长期的效果(例如经由基因表示的 neuroprotection )。另外， nAChR 活动能被细胞质的钙层次调整，建议一种复杂相互的关系。在为 neuronal nAChRs 的成像技术，动物模型，和更多的有势力和子类型选择的 ligands 的进一步的进展将在理解 neuronal 帮助发信号的调停 nAChR 的钙，并且导致改进治疗学的处理的发展。" @default.
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- W3141453396 date "2009-01-01" @default.
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- W3141453396 title "Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system" @default.
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