FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3141498550> ?p ?o ?g. }

• W3141498550 abstract "The emergence of SARS-CoV-2 Variants of Concern (VOCs) with mutations in key neutralizing antibody epitopes threatens to undermine vaccines developed against the pandemic founder variant (Wu-Hu-1). Widespread vaccine rollout and continued transmission are creating a population that has antibody responses of varying potency to Wu-Hu-1. Against this background, it is critical to assess the outcomes of subsequent immunization with variant antigens. It is not yet known whether heterotypic vaccine boosts would be compromised by original antigenic sin, where pre-existing responses to a prior variant dampen responses to a new one, or whether the primed memory B cell repertoire would bridge the gap between Wu-Hu-1 and VOCs. Here, we show that a single adjuvanted dose of receptor binding domain (RBD) protein from VOC 501Y.V2 (B.1.351) drives an extremely potent neutralizing antibody response capable of cross-neutralizing both Wu-Hu-1 and 501Y.V2 in rhesus macaques previously immunized with Wu-Hu-1 spike protein. Passive immunization with plasma sampled following this boost protected K18-hACE2 mice from lethal challenge with a 501Y.V2 clinical isolate, whereas only partial protection was afforded by plasma sampled after two Wu-Hu-1 spike immunizations." @default.
• W3141498550 created "2021-04-13" @default.
• W3141498550 creator A5009866343 @default.
• W3141498550 creator A5011295470 @default.
• W3141498550 creator A5012267353 @default.
• W3141498550 creator A5016245751 @default.
• W3141498550 creator A5029399205 @default.
• W3141498550 creator A5030148261 @default.
• W3141498550 creator A5032186481 @default.
• W3141498550 creator A5033401033 @default.
• W3141498550 creator A5055329270 @default.
• W3141498550 creator A5057272912 @default.
• W3141498550 creator A5063723073 @default.
• W3141498550 creator A5081300518 @default.
• W3141498550 creator A5089160183 @default.
• W3141498550 date "2021-04-05" @default.
• W3141498550 modified "2023-10-17" @default.
• W3141498550 title "Driving potent neutralization of a SARS-CoV-2 Variant of Concern with a heterotypic boost" @default.
• W3141498550 cites W2013492992 @default.
• W3141498550 cites W2043343078 @default.
• W3141498550 cites W2074618762 @default.
• W3141498550 cites W2557207823 @default.
• W3141498550 cites W3001195213 @default.
• W3141498550 cites W3003217347 @default.
• W3141498550 cites W3014067025 @default.
• W3141498550 cites W3044914269 @default.
• W3141498550 cites W3080378920 @default.
• W3141498550 cites W3081892744 @default.
• W3141498550 cites W3108610942 @default.
• W3141498550 cites W3111038302 @default.
• W3141498550 cites W3111255098 @default.
• W3141498550 cites W3116015992 @default.
• W3141498550 cites W3121332187 @default.
• W3141498550 cites W3123053754 @default.
• W3141498550 cites W3127329393 @default.
• W3141498550 cites W3130724183 @default.
• W3141498550 cites W3131995220 @default.
• W3141498550 cites W3134141435 @default.
• W3141498550 cites W3142193311 @default.
• W3141498550 cites W3148277587 @default.
• W3141498550 cites W3151623025 @default.
• W3141498550 cites W3155578042 @default.
• W3141498550 cites W3156468949 @default.
• W3141498550 cites W3157162195 @default.
• W3141498550 cites W3158136279 @default.
• W3141498550 cites W4205483821 @default.
• W3141498550 cites W4232949030 @default.
• W3141498550 doi "https://doi.org/10.1101/2021.04.03.438330" @default.
• W3141498550 hasPublicationYear "2021" @default.
• W3141498550 type Work @default.
• W3141498550 sameAs 3141498550 @default.
• W3141498550 citedByCount "1" @default.
• W3141498550 countsByYear W31414985502021 @default.
• W3141498550 crossrefType "posted-content" @default.
• W3141498550 hasAuthorship W3141498550A5009866343 @default.
• W3141498550 hasAuthorship W3141498550A5011295470 @default.
• W3141498550 hasAuthorship W3141498550A5012267353 @default.
• W3141498550 hasAuthorship W3141498550A5016245751 @default.
• W3141498550 hasAuthorship W3141498550A5029399205 @default.
• W3141498550 hasAuthorship W3141498550A5030148261 @default.
• W3141498550 hasAuthorship W3141498550A5032186481 @default.
• W3141498550 hasAuthorship W3141498550A5033401033 @default.
• W3141498550 hasAuthorship W3141498550A5055329270 @default.
• W3141498550 hasAuthorship W3141498550A5057272912 @default.
• W3141498550 hasAuthorship W3141498550A5063723073 @default.
• W3141498550 hasAuthorship W3141498550A5081300518 @default.
• W3141498550 hasAuthorship W3141498550A5089160183 @default.
• W3141498550 hasBestOaLocation W31414985501 @default.
• W3141498550 hasConcept C14086860 @default.
• W3141498550 hasConcept C142724271 @default.
• W3141498550 hasConcept C147483822 @default.
• W3141498550 hasConcept C159047783 @default.
• W3141498550 hasConcept C159654299 @default.
• W3141498550 hasConcept C195616568 @default.
• W3141498550 hasConcept C202751555 @default.
• W3141498550 hasConcept C203014093 @default.
• W3141498550 hasConcept C2779134260 @default.
• W3141498550 hasConcept C2779261636 @default.
• W3141498550 hasConcept C2780801004 @default.
• W3141498550 hasConcept C2908647359 @default.
• W3141498550 hasConcept C2909509916 @default.
• W3141498550 hasConcept C3008058167 @default.
• W3141498550 hasConcept C3018027319 @default.
• W3141498550 hasConcept C3018913218 @default.
• W3141498550 hasConcept C524204448 @default.
• W3141498550 hasConcept C54355233 @default.
• W3141498550 hasConcept C57992300 @default.
• W3141498550 hasConcept C71924100 @default.
• W3141498550 hasConcept C86803240 @default.
• W3141498550 hasConcept C99454951 @default.
• W3141498550 hasConceptScore W3141498550C14086860 @default.
• W3141498550 hasConceptScore W3141498550C142724271 @default.
• W3141498550 hasConceptScore W3141498550C147483822 @default.
• W3141498550 hasConceptScore W3141498550C159047783 @default.
• W3141498550 hasConceptScore W3141498550C159654299 @default.
• W3141498550 hasConceptScore W3141498550C195616568 @default.
• W3141498550 hasConceptScore W3141498550C202751555 @default.
• W3141498550 hasConceptScore W3141498550C203014093 @default.
• W3141498550 hasConceptScore W3141498550C2779134260 @default.
• W3141498550 hasConceptScore W3141498550C2779261636 @default.

• next