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- W3141502016 abstract "肺癌症是癌症相关的死亡的领先的原因在中国并且全球，与非小的房间肺癌症(NSCLC ) 为 80% 所有肺癌症的财务。尽管有在临床的策略的改进，在药品治疗以后的 5 年的幸存率仍然是很差的[1,2 ] 。KRAS 变化被发现是显著地在腺癌病人更经常[3 ] 。p53 抄写因素是批评肿瘤 suppressor，作为由它在所有人的癌症的一半上被变异在并且 p53 0 老鼠与 100% 外显率得癌症的观察证实了[4 ] 。而且，有 p53/LKB1 损失的 KRAS 变化的存在在现出症状之前的潜的鼠科的模型授与更坏的结果并且为到 selumetinib 和 docetaxel 的抵抗是预兆的[5 ] 。到对待人 NSCLC，因此，更好的目标的鉴定基于背景遗传型成为了最大的重要性的一个立即的目标，并且为新、更有效的策略的发展关键。" @default.
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- W3141502016 date "2016-01-01" @default.
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- W3141502016 title "miRNAs associated with the malignant transformation of non-small cell lung cancer" @default.
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